ArticleCureus2026
Denture-Related Irritation Fibroma With Myxoid Change of the Anterior Hard Palate: A Clinicopathologic Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Denture-related irritation fibroma is a common reactive lesion of the oral mucosa caused by chronic mechanical irritation; however, cases arising on the anterior hard palate and exhibiting prominent myxoid stromal change are rare. A 54-year-old man presented with a long-standing, pedunculated mass (16 × 20 × 11 mm) on the right anterior hard palate in the setting of long-term maxillary complete denture use. After an incisional biopsy revealed moderate epithelial dysplasia, the lesion was excised under local anesthesia with a 2 mm safety margin at the stalk and subperiosteal dissection. Histopathology revealed a fibrous nodule covered by stratified squamous epithelium with hyperkeratosis and acanthosis, and a well-demarcated area of myxoid matrix immediately beneath the epithelium. Alcian blue (AB) staining showed diffuse stromal positivity, and immunohistochemistry demonstrated a very low Ki-67 labeling index and broad-spectrum cytokeratin (CK-wide) negativity in the lesional stroma, with diffuse epithelial positivity as an internal control, supporting a diagnosis of denture-related irritation fibroma with myxoid stromal change. Postoperative healing was uneventful, and no recurrence was observed after denture adjustment and improvement of denture hygiene. In this report, we present a case of denture-related irritation fibroma with moderate epithelial dysplasia and prominent myxoid stromal change that had remained untreated and progressively enlarged over approximately 20 years.
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