Evidence map›Paper›PMID 42017095›Full record

ReviewCureus2026

Traumatic Brain Injury and Axonal Damage in the Pathogenesis of Frontotemporal Dementia: A Narrative Review.

Saad A Farooqui, Fozia Farooqui

Abstract readReview
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Saad A FarooquiDepartment of Emergency Medicine, Saint Mary Medical Center, Langhorne, USA.
Fozia FarooquiDepartment of Hospital Medicine, Temple University Hospital, Philadelphia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) has emerged as a critical environmental risk factor for the development of frontotemporal dementia (FTD), a neurodegenerative disorder characterized by progressive declines in executive function, behavior, and language. While the acute symptoms of head trauma often resolve, the long-term neurological consequences can include a significant increase in FTD susceptibility. A comprehensive search of electronic databases, including PubMed and Google Scholar, was conducted to identify relevant peer-reviewed studies published through 2026. This review examines the complex pathological mechanisms linking blunt force trauma to frontotemporal degeneration, specifically focusing on the role of traumatic axonal injury (TAI) and the subsequent accumulation of beta-amyloid plaques alongside related FTD-associated proteinopathies.

Indexed as

amyloid beta plaquefrontotemporal dementia (ftd)role of neuronstraumatic axonal injurytraumatic brain injury (tbi)

Identifiers

PMID42017095
PMCPMC13093862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.