ArticleCureus2026
Management of Cushing's Disease in Pregnancy: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cushing's syndrome (CS) is a rare condition encountered in pregnancy, and Cushing's disease (pituitary-dependent CS) represents an even smaller subset. The occurrence of pregnancy in women with CS is uncommon because hypercortisolism suppresses the hypothalamic-pituitary-gonadal axis, frequently leading to anovulation and infertility. When conception does occur, Cushing's disease can significantly complicate the course of pregnancy, posing serious risks to both the mother and fetus. Reported maternal complications include hypertension, gestational diabetes mellitus, pre-eclampsia, heart failure, and increased susceptibility to infections, while fetal complications include growth restriction, preterm birth, and intrauterine demise. We present a case of a 33-year-old woman with a long history of non-specific symptoms, later confirmed to be due to Cushing's disease secondary to a pituitary microadenoma. Remarkably, she conceived spontaneously before undergoing definitive therapy. Throughout pregnancy, she was managed conservatively under close multidisciplinary supervision, involving endocrinology, obstetrics, and neonatology teams. The optimal management of CS during pregnancy remains controversial, as therapeutic decisions must balance the risks of uncontrolled hypercortisolism against the potential harms of surgical or medical interventions during gestation. In this case, given the stability of maternal and fetal status, a conservative approach was chosen. Despite the challenges posed by physiological changes in pregnancy and the elevated risks associated with CS, the patient's pregnancy progressed without major complications. She ultimately delivered a healthy term infant via planned elective cesarean section. This case highlights the critical importance of individualized, patient-centered care and reinforces the value of multidisciplinary collaboration in managing such high-risk pregnancies. It also suggests that, in carefully selected patients, conservative management can be a safe and effective strategy, leading to favorable maternal and neonatal outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.