Evidence map›Paper›PMID 42017054›Full record

ArticleNature electronics2025

A programmable and self-adaptive ultrasonic wireless implant for personalized chronic pain management.

Yushun Zeng, Chen Gong, Gengxi Lu, Jianxing Wu, Xiao Wan, Yang Yang, Jie Ji, Junhang Zhang, Runze Li, Yizhe Sun and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature electronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Recent advances in transducers for through-tissue ultrasonic power transfer.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  6. Organoid Brain-Machine-Interface Devices for Central Nervous System Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yushun ZengAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-5995-4085
Chen GongAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6262-704X
Gengxi LuAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-7497-050X
Jianxing WuDepartment of Electrical Engineering, National Chin-Yi University of Technology, Taichung City, Taiwan.ORCID 0000-0002-9327-7396
Xiao WanDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Yang YangDepartment of Mechanical Engineering, San Diego State University, San Diego, CA, USA.ORCID 0000-0002-4032-5446
Jie JiAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Junhang ZhangAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-7847-3102
Runze LiAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6642-5904
Yizhe SunAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9291-0076
Ziyuan CheDepartment of Bioengineering, University of California, Los Angeles, CA, USA.
Chi-Feng ChangAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Hsiao-Chuan LiuRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-5410-8821
Jiawen ChenDepartment of Neurobiology, University of Southern California, Los Angeles, CA, USA.
Qingqing HeDepartment of Mechanical Engineering, San Diego State University, San Diego, CA, USA.ORCID 0009-0002-2379-060X
Xin SunAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Ruitong ChenAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-3892-9221
Sina Khazaee NejadAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Xunan LiuAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Deepthi S Rajendran NairRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-8851-5241
Laiming JiangAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8658-3168
Jun ChenDepartment of Bioengineering, University of California, Los Angeles, CA, USA.ORCID 0000-0002-3439-0495
Qifa ZhouAlfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1527-3020

Funding

The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
Magnetoelastic Vascular GraftsR01HL175135 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jun Chen · 2025 to 2026
$1.1M
A soft magnetoelastic microneedle patch for rapid skin cancer screeningR01CA287326 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jun Chen · 2024 to 2026
$1.1M
Development of two-dimensional (2D) acoustic force elastography microscopy for the non-contact measurement of elastic property of cell encapsulated scaffoldsR21GM154167 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, HSIAO-CHUAN · 2024 to 2025
$410k
Development of non-contact rheometry for measuring rheological properties of biological fluidsR03EB032958 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, HSIAO-CHUAN · 2022 to 2023
$165k
American Heart Association-American Stroke Association 23IPA1054908American Heart Association-American Stroke Association 23SCEFIA1157587American Heart Association-American Stroke Association 23TPA1141360NCATS NIH HHS KL2 TR001882NCI NIH HHS R01 CA287326NHLBI NIH HHS R01 HL175135NIBIB NIH HHS R03 EB032958NIGMS NIH HHS R21 GM154167
6 · The paper itself

Abstract

Chronic pain management typically involves opioids, which are associated with severe side effects such as addiction. Implantable percutaneous electrical stimulators are a promising alternative approach to pain management. However, they are expensive, can cause damage during surgery and often rely on a battery power supply that must be periodically replaced. Here we report an integrated flexible ultrasound-induced wireless implantable stimulator combined with a pain detection and management system for personalized chronic pain management. Power is supplied to the stimulator by a wearable ultrasound transmitter. We classify pain stimuli from brain recordings by developing a machine learning model and program the acoustic energy from the ultrasound transmitter and therefore the intensity of electrical stimulation. We show that the implant can generate targeted, self-adaptive and quantitative electrical stimulations to the spinal cord according to the classified pain levels for chronic pain management in free-moving animal models.

Identifiers

PMID42017054
PMCPMC13095316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.