Evidence map›Paper›PMID 42016923›Full record

ArticleFrontiers in pharmacology2026

Interleukin-17 and interleukin-10 in the adenoid hypertrophy children concomitant with otitis media with effusion.

Yuyan Yan, Lujie Zuo, Yafang Wang, Li Cui, Yingluan Song, Li Wang, Xiaofeng Liu, Hongbo Wang, Jiangqiao Geng

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yuyan Yan *Department of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Lujie Zuo *Department of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Yafang WangDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Li CuiDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Yingluan SongDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Li WangDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Xiaofeng LiuDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Hongbo WangDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.
Jiangqiao GengDepartment of Otolaryngology, Head and Neck Surgery, Children's Hospital of Hebei Province, Hebei Provincial Clinical Research Center for Child Health and Disease, Shijiazhuang, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Adenoid hypertrophy (AH) is a prevalent cause of otitis media with effusion (OME) in children, although its pathogenesis remains poorly understood. The objective of this study is to assess the levels of interleukin-17 (IL-17) and interleukin-10 (IL-10) in children with isolated AH and those with AH in conjunction with OME. Methods: Thirty children with AH and OME who underwent adenoidectomy and tympanostomy tube placement were included in the OME group, whereas 30 children with isolated AH who underwent adenoidectomy were included in the AH group. Adenoid tissue samples were collected during surgery, and preoperative venous blood samples were acquired. Concentrations of IL-17 and IL-10 in both adenoid tissue and serum were measured using enzyme-linked immunosorbent assay (ELISA). Results: Levels of IL-17 (4.20 ± 1.51 ng/mL) and IL-10 (3.77 ± 1.06 ng/mL) in adenoid tissue were significantly lower in the OME group than in the AH group (5.29 ± 2.16 ng/mL and 4.80 ± 1.93 ng/mL, respectively; P < 0.05). No significant differences in serum levels of IL-17 or IL-10 were observed between the two groups (P > 0.05). ROC analysis revealed that adenoid tissue IL-17 and IL-10 exhibited higher AUC values, specificity, and sensitivity for predicting AH in combination with OME compared to their serum counterparts (P < 0.05). Conclusion: The reduced local expression of IL-17 and IL-10 in adenoid tissue is associated with the development of OME in children with AH. Targeting these cytokines may provide potential therapeutic strategies for preventing or treating AH-related OME.

Indexed as

adenoidal hypertrophycytokinesinterleukin-10interleukin-17otitis media with effusion

Identifiers

PMID42016923
PMCPMC13095179

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