ArticleACS catalysis2024
Controllable Multihalogenation of a Non-native Substrate by the SyrB2 Iron Halogenase.
Article in ACS catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Rational design of tertiary coordination sphere of a heme-based sensor for two-orders enhanced oxygen affinity.bioRxiv : the preprint server for biology · 2025Article
- Sequential oxidation of L-lysine by a non-heme iron hydroxylase.bioRxiv : the preprint server for biology · 2025Article
- Machine Learning Guided Rational Design of a Non-Heme Iron-Based Lysine Dioxygenase Improves its Total Turnover Number.Chembiochem : a European journal of chemical biology · 2024Article
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Abstract
Geminal, multihalogenated functional groups are widespread in natural products and pharmaceuticals, yet no synthetic methodologies exist that enable selective multihalogenation of unactivated C-H bonds. Biocatalysts are powerful tools for late-stage C-H functionalization as they operate with high degrees of regio-, chemo-, and stereoselectivity. 2-Oxoglutarate (2OG)-dependent nonheme iron halogenases chlorinate and brominate aliphatic C-H bonds and offer a solution for achieving these challenging transformations. Here, we describe the ability of a nonheme iron halogenase, SyrB2, to controllably halogenate a non-native substrate
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