ArticleExploration (Beijing, China)2026
Modification-Response Integrated Modules Driven Cyclization-Dependent Prodrug Self-Assembly for Reshaping Pro-Apoptotic Tumor Redox Homeostasis.
Article in Exploration (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Natural Product-Based Nanomedicine in the Treatment of Breast Cancer.Pharmaceutics · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Affected by the complexity and heterogeneity of the tumor redox microenvironment, chemotherapy often fails to achieve satisfactory clinical outcomes. Modular design of prodrug nanoassemblies presents tremendous potential in upgrading the therapeutic index of chemotherapeutic agents. Given the biochemical vulnerability of tumor redox homeostasis, we fabricated five-membered cyclic chalcogenide-linked paclitaxel prodrug nanoassemblies, which realized tumor site-specific activation and reshaped the pro-apoptotic tumor redox homeostasis. Cyclic diselenide and cyclic disulfide bonds integrated the modification modules and response modules to minimize the utilization of non-pharmacodynamic moieties and increase druggability. Importantly, the modification-response integrated modules could simultaneously block the glutathione-glutathione peroxidase (GSH/GPx) antioxidant system and amplify reactive oxygen species (ROS) generation. The reshaping of the tumor redox homeostasis cascade triggered the loss of mitochondrial membrane potential and apoptosis of tumor cells, which synergistically potentiated the antitumor effects of paclitaxel. Such an intelligent prodrug nanoplatform brought new perspectives for constructing advanced antitumor nanomedicines with significant clinical research value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.