Evidence map›Paper›PMID 42016748›Full record

ArticleExploration (Beijing, China)2026

Autologous Extracellular Matrix-Based Cell-Free Therapy for Tissue Regeneration Through Trem2

Mengmeng Hou, Nini Shi, Yajie Guo, Jiezhang Tang, Han Peng, Baoyan Liang, Yixuan Yu, Chenggang Yi, Huichen Li

Abstract read
In one paragraph

Article in Exploration (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengmeng HouDepartment of Plastic Surgery Xijing Hospital Fourth Military Medical University Xi'an China.
Nini ShiMilitary Medical Innovation Center Fourth Military Medical University Xi'an China.
Yajie GuoDepartment of Plastic Surgery Xijing Hospital Fourth Military Medical University Xi'an China.
Jiezhang TangDepartment of Plastic Surgery and Burns Tangdu Hospital Fourth Military Medical University Xi'an China.
Han PengDepartment of Plastic Surgery Xijing Hospital Fourth Military Medical University Xi'an China.
Baoyan LiangDepartment of Plastic Surgery Xijing Hospital Fourth Military Medical University Xi'an China.
Yixuan YuDepartment of Plastic Surgery Xijing Hospital Fourth Military Medical University Xi'an China.
Chenggang YiThe Second Affiliated Hospital of Zhejiang University College of Medicine Hangzhou China.
Huichen LiDepartment of Plastic Surgery Xijing Hospital Fourth Military Medical University Xi'an China.ORCID https://orcid.org/0000-0002-5861-4465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular matrix (ECM) is vital for tissue regeneration and remodeling by providing structural support and regulating cell behavior. Bioactive membranes derived from decellularized ECM show promising regenerative potential in many fields. However, they still face challenges such as immune rejection, structural disparities, and high costs associated with human-derived materials. These issues hinder their widespread clinical application and limit their adaptability to personalized treatments. Further research is needed to improve the safety, efficacy, and accessibility of ECM-based materials. This study develops an autologous ECM-based membrane, termed adipose-derived matrix film (ADF), using a simple physical method inspired by traditional "

Indexed as

adipose‐derived matrix filmangiogenesiscell‐free therapyextracellular matrixtissue regeneration

Identifiers

PMID42016748
PMCPMC13094522

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.