ArticleJournal of oral microbiology2026
Nonsurgical periodontal therapy remodels oral microbiome-metabolome networks and associates with glycemic and inflammatory improvements in type 2 diabetes mellitus with periodontitis: a 6-month longitudinal study.
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Clarifying treatment attribution and lesion-level signals in periodontal multi-omics for diabetes.Journal of oral microbiology · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Periodontitis and type 2 diabetes mellitus (T2DM) have a bidirectional relationship, yet how nonsurgical periodontal therapy (NSPT) affects oral microbiome-metabolome interactions in this comorbidity remains unclear. Objective: To longitudinally characterize oral microbiome and metabolome shifts following NSPT in patients with T2DM and periodontitis, and to relate these shifts to periodontal and systemic outcomes. Design: A total of 42 participants completed the 6-month follow-up. At baseline, they were randomly assigned to NSPT (supragingival scaling plus scaling and root planning, Results: NSPT improved periodontal inflammation and was accompanied by favorable changes in systemic inflammation and glucose/lipid indices; HbA1c reduction was more pronounced in those with poorer baseline glycemic control. Both groups showed temporal variability in microbiome and metabolome profiles, but the taxa/metabolites that changed differed between groups. Changes in bleeding index correlated positively with 13-eicosenoic acid, xylose, Conclusion: NSPT reshapes oral microbe-metabolite networks in T2DM with periodontitis, implicating redox-related pathways that may link periodontal therapy to systemic inflammation and glycemic control.
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