Evidence map›Paper›PMID 42016676›Full record

ArticleClinical case reports2026

Renal-Limited Thrombotic Microangiopathy due to Anti-VEGF/TKI Immunotherapy for Metastatic Renal Cell Carcinoma Presenting as Nephrotic Syndrome: A Case Report and Literature Review.

Sundus Sardar, Ahmad Matarneh, Omar K Salameh, Abdel-Rauof M Akkari, Monika Joshi, Erik Washburn, Nasrollah Ghahramani, Naman Trivedi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sundus SardarPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.ORCID https://orcid.org/0000-0002-1727-0520
Ahmad MatarnehPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.
Omar K SalamehPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.ORCID https://orcid.org/0000-0002-9190-0439
Abdel-Rauof M AkkariPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.
Monika JoshiPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.
Erik WashburnPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.
Nasrollah GhahramaniPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.
Naman TrivediPenn State Milton S Hershey Medical Center Hershey Pennsylvania USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial growth factor (VEGF) inhibition may result in proteinuria, worsening hypertension, chronic kidney injury, or glomerular disease. Recently, systemic VEGF inhibition has been reported to cause nephrotic disorders and thrombotic microangiopathy (TMA). We present a unique case of renal-limited TMA presenting as nephrotic syndrome in a patient on anti-VEGF/TKI immunotherapy and immune checkpoint inhibitors for metastatic renal cell carcinoma.

Indexed as

hypertensionnephrotic syndromeproteinuriathrombotic microangiopathyvascular endothelial growth factor inhibitor

Identifiers

PMID42016676
PMCPMC13093660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.