ArticleJournal of the Endocrine Society2026
Association between high DHEAS in 7-year-old girls and metabolic features 4 years after menarche.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Premature adrenarche is linked to increased adiposity, enhanced adrenal 11-oxygenated C19 androgen production, and adverse metabolic profiles in childhood. However, it remains unclear whether early elevations in dehydroepiandrosterone sulfate (DHEAS) predict metabolic dysfunction in adolescence or young adulthood. Methods: This longitudinal study included girls from the Growth and Obesity Chilean Cohort Study, all with normal birth weight. DHEAS was measured at ∼7 years (n = 504, 68% follow-up), and participants were reevaluated 4 years after menarche (4YPM, ∼16 years). Girls were classified as having high DHEAS (HD; >75th percentile) or normal DHEAS (ND; ≤75th percentile). Anthropometric, metabolic, and hormonal parameters, including 11-oxygenated C19 steroids, were compared between groups. Results: At 4YPM, HD girls (n = 96) showed higher body mass index SD score ( Conclusion: Elevated DHEAS at adrenarche persists after puberty without higher bioactive 11-oxosteroids or significant metabolic deterioration, suggesting attenuation of early adverse metabolic features by mid-adolescence.
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