Evidence map›Paper›PMID 42016472›Full record

ArticleAdvanced functional materials2026

DNA Helix Bundle-Encoded Multi-Bit Information Readout by Sapphire-Supported Nanopores.

Pengkun Xia, Deeksha Satyabola, Nimarpreet Kaur Bamrah, Md Ashiqur Rahman Laskar, Abdulla Al Mamun, Xu Zhou, Gde Bimananda Mahardika Wisna, Yinan Zhang, Ashif Ikbal, Andrew Kemeklis and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pengkun XiaSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0001-5097-5576
Deeksha SatyabolaBiodesign Center for Molecular Design & Biomimetics, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0003-0960-8103
Nimarpreet Kaur BamrahSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.
Md Ashiqur Rahman LaskarSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-4419-0614
Abdulla Al MamunSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-8575-5618
Xu ZhouBiodesign Center for Molecular Design & Biomimetics, Arizona State University, Tempe, AZ 85287, USA.
Gde Bimananda Mahardika WisnaBiodesign Center for Molecular Design & Biomimetics, Arizona State University, Tempe, AZ 85287, USA.
Yinan ZhangBiodesign Center for Molecular Design & Biomimetics, Arizona State University, Tempe, AZ 85287, USA.
Ashif IkbalSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.
Andrew KemeklisSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.
Alexandra E KrylovaDepartment of Biomedical Engineering, the University of Texas at Austin, TX 78712, USA.
Rizal HariadiBiodesign Center for Molecular Design & Biomimetics, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0001-7840-859X
Hao YanBiodesign Center for Molecular Design & Biomimetics, Arizona State University, Tempe, AZ 85287, USA.
Chao WangSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0001-5020-961X

Funding

Integrated Nano-Opto-Fluidic System on Sapphire towards Single-Molecule Protein SequencingDP2GM149552 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, CHAO · 2022 to 2025
$2.2M
NIGMS NIH HHS DP2 GM149552
6 · The paper itself

Abstract

The increasing demand for high-capacity data storage continues to drive innovation in memory technologies. DNA has emerged as a promising high-density data storage medium. Data storage using DNA nanostructures is compatible with complex data encoding schemes and simple readout methods, e.g. solid-state nanopores. Here, we propose and demonstrate the use of sapphire-supported, low-noise nanopores to detect nanostructured DNA tagged onto four-helix bundle (4HB) DNA as a flexibly programmable and secure scheme for readout, achieving a high signal-to-noise ratio (~22) under 250 kHz filtering frequency. With the aid of decision-tree supervised learning, up to ~93% of the messages are correctly classified, proving the feasibility of encoding letters and messages for information retrieval.

Indexed as

CryptographyData encryptionDNA origamiDNA storageHelix bundlesLow-noise sensingSapphire-supported nanopores

Identifiers

PMID42016472
PMCPMC13095159

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.