Clinical Outcomes of Hypoglossal Nerve Stimulation Versus Continuous Positive Airway Pressure in Obstructive Sleep Apnea.

Amala Nayak, Iman Adibi, Alyssa Calder, Arman Saeedi, Aaron Tucker, Ryan Nord

Abstract read

In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amala NayakDepartment of Otolaryngology-Head and Neck Surgery Virginia Commonwealth University School of Medicine Richmond PO BOX Virginia USA.ORCID https://orcid.org/0009-0007-8881-8921

Iman AdibiDepartment of Otolaryngology-Head and Neck Surgery Virginia Commonwealth University School of Medicine Richmond PO BOX Virginia USA.ORCID https://orcid.org/0009-0005-6746-4824

Alyssa CalderDepartment of Otolaryngology-Head and Neck Surgery Virginia Commonwealth University School of Medicine Richmond PO BOX Virginia USA.ORCID https://orcid.org/0000-0001-8863-0573

Arman SaeediDepartment of Otolaryngology-Head and Neck Surgery Virginia Commonwealth University School of Medicine Richmond PO BOX Virginia USA.ORCID https://orcid.org/0000-0003-3396-0115

Aaron TuckerDepartment of Otolaryngology-Head and Neck Surgery Virginia Commonwealth University School of Medicine Richmond PO BOX Virginia USA.ORCID https://orcid.org/0009-0005-6243-276X

Ryan NordDepartment of Otolaryngology-Head and Neck Surgery Virginia Commonwealth University School of Medicine Richmond PO BOX Virginia USA.ORCID https://orcid.org/0000-0001-6415-8948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Obstructive sleep apnea (OSA) is linked to cardiovascular, metabolic, and neuropsychiatric morbidity. Continuous positive airway pressure (CPAP) remains first-line therapy, but poor adherence limits effectiveness. Hypoglossal nerve stimulation (HNS) is an emerging alternative for CPAP-intolerant patients. This study compared clinical outcomes between HNS and CPAP in OSA patients. Study Design: Retrospective Cohort Study. Setting: TriNetX Research Network. Methods: We identified adults with OSA who underwent HNS implantation or initiated CPAP therapy, with 2 years of follow-up. Propensity score matching (n = 3525 per group) balanced baseline demographics and comorbidities. Acute cardiovascular, respiratory, and metabolic outcomes were assessed from 30 days posttreatment to 2 years. A similar analysis was performed to compare health outcomes of HNS and uvulopalatopharyngoplasty (UPPP) surgery without future CPAP use. Results: The HNS cohort had significantly lower odds of stroke (odds ratio [OR] 0.626, Conclusion: HNS may offer systemic benefits and reduce healthcare burden compared to CPAP. Future studies should incorporate adherence data and cost-effective analyses to guide treatment.

Indexed as

continuous positive airway pressurehypoglossal nerve stimulationobstructive sleep apnea

Identifiers

PMID42016453

DOI10.1002/oto2.70240

PMCPMC13093420

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.