ArticleJournal of clinical medicine research2026
Factors Predicting Diuretic Resistance in Patients With Acute Decompensated Heart Failure.
Article in Journal of clinical medicine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute decompensated heart failure (ADHF) is a leading cause of mortality and morbidity in the world. Diuretic resistance occurs in 20-30% of patients with ADHF and is an independent predictor of worsening clinical outcomes, immediate post-treatment death, and re-admission events. This study aims to: 1) identify factors that influence the occurrence of diuretic resistance in ADHF patients based on the underlying disease, comorbidities, vital signs, left ventricular ejection fraction, and laboratory parameters, and 2) investigate the clinical characteristics that serve as indicators of diuretic resistance incidence in patients with ADHF. Methods: A retrospective cohort study was conducted on 535 patients treated with ADHF during the period from January to December 2019. Diuretic resistance was defined as a diuresis response of less than 1,400 mL in the first 24 h after administration of 40 mg of intravenous (IV) furosemide (or equivalent). Subjects were observed for 24 h post 40 mg IV furosemide for occurrence of diuretic resistance. Bivariate and multivariate analyses were performed to synthesize clinical scoring system to predict occurrence of diuretic resistance. Results: Diuretic resistance occurs in 68% of patients. Independent predictors obtained from multivariate logistic regression analysis were: history of diabetes mellitus (DM, P = 0.013), history of using IV loop diuretics > 6 days (P = 0.002), oral loop diuretic dose > 80 mg/day (P = 0.006), left ventricular ejection fraction (LVEF) ≤ 49% (P = 0.002), blood urea nitrogen (BUN) ≥ 21 mg/dL (P < 0.001), and serum chloride < 98 mmol/L (P < 0.001). In addition, a scoring system has been made from the final model. Conclusion: DM, history of IV loop diuretic, daily loop diuretic dosage, LVEF < 49%, BUN > 21 mg/dL, and serum chloride < 98 mmol/L were found to be statistically significant in association with occurrence of diuretic resistance using multivariate analysis and can be synthesized into a clinical scoring system to help predict diuretic resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.