Octopus sucker-inspired, Turkish gall extract-integrated microneedle patch for oral ulcer mitigation.

Lin Lin, Shilin Guo, Cheng Zhao, Xiaotan Dou, Wei Han, Chuanhui Song

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lin LinNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 210008, China.

Shilin GuoNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 210008, China.

Cheng ZhaoDepartment of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.

Xiaotan DouDepartment of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.

Wei HanNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 210008, China.

Chuanhui SongNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 210008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite pharmacological advancements of oral ulcer treatment, developing sustained-release delivery systems remains a challenge. To address this, we designed a bioinspired microneedle platform integrating Turkish gall extract for targeted ulcer therapy. Drawing on the structural principles of octopus suckers, we fabricated a 3D-printed microneedle array with suction-enhanced morphology, replicated into a hydrogel-based mold. The microneedle matrix was synthesized by combining Turkish gall extract, polydopamine, and hyaluronic acid methacrylate, leveraging polydopamine's catechol chemistry for robust mucoadhesion. Pharmacological evaluations confirmed the dual functionality of the herbal component, demonstrating dose-dependent anti-inflammatory and anti-oxidant effects

Indexed as

Biomedical engineeringMaterials sciencePharmacology

Identifiers

PMID42016310

DOI10.1016/j.isci.2026.115557

PMCPMC13092480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.