ArticleiScience2026
An integrated
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studying synaptic transmission is facilitated in experimental systems that isolate individual neuronal connections. We developed an integrated platform combining polydimethylsiloxane (PDMS) microstructures with high-density microelectrode arrays to isolate, record, and manipulate neuronal pairs from human induced pluripotent stem cell (hiPSC)-derived neurons. The system maintained hundreds of parallel neuronal pairs for over 100 days, demonstrating functional synapses through pharmacological validation. We coupled this platform with a biophysical Hodgkin-Huxley model and simulation-based inference to extract mechanistic parameters from the electrophysiological data. As a proof-of-concept application, we analyzed shifts in model parameter distributions following a stimulation protocol. The biophysical model revealed α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor-specific alterations after stimulation, providing quantitative insights into synaptic plasticity mechanisms. This integrated approach combines isolated hiPSC-derived synaptic pairs, stable parallel long-term recordings, and mechanistic modeling to enable systematic studies of human synaptic transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.