ArticleFood science & nutrition2026
Unveiling the Immunopharmacological Mechanisms of Biejiajian Pills (BJJP) Underlying the Treatment of Hepatic Fibrosis: Insights From Network Pharmacology and Experimental Validation.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biejiajian Pills (BJJP) have demonstrated certain therapeutic effects in the treatment of hepatic fibrosis (HF) in Traditional Chinese medicine practice. However, their underlying mechanism of action remains unclear. This study aimed to investigate the primary compounds of BJJP and their potential mechanisms in treating HF through network pharmacology and experimental validation. By integrating network pharmacology with RF, SVM-RFE, and LASSO algorithms, this study identified that the therapeutic effect of BJJP on HF may be mediated by two signature genes, LYN and CFTR, which were further validated using a validation set. Molecular docking results showed that the main compounds of BJJP, including six compounds such as kaempferol and baicalein, have a strong binding affinity with LYN and CFTR. Through the ssGSEA algorithm, we found that the proportions of six immune cell subsets, including M1 macrophages, M2 macrophages, and resting memory CD4
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.