ArticleEFSA journal. European Food Safety Authority2012
Scientific Opinion on the Tolerable Upper Intake Level of calcium.
Article in EFSA journal. European Food Safety Authority, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Calcium supplementation for people with overweight or obesity.The Cochrane database of systematic reviews · 2024Pooled it
- Efficacy and safety of vitamin D supplementation on psoriasis: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Pooled it
- Vitamin D supplementation does not enhance resistance training-induced gains in muscle strength and lean body mass in vitamin D deficient young men.European journal of applied physiology · 2021Trial
- Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults.Aging clinical and experimental research · 2020Trial
- Assessment of trace element distribution, bioaccumulation, and health risks in silver pomfret from major fishing grounds of the Bay of Bengal.Scientific reports · 2026Article
- Vitamin D Fortification of Dairy Products in the United Kingdom: What Are the Barriers?Advances in nutrition (Bethesda, Md.) · 2026Review
- Evaluation of the Elemental Composition of Dietary Supplements Containing Iron Available on the Polish Market Using ICP-OES, FAAS and CVAAS Techniques.Molecules (Basel, Switzerland) · 2025Article
- Calcium sulphate and reduction in body weight: Evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006.EFSA journal. European Food Safety Authority · 2025Article
- Sustainable Meat Alternatives: Incorporation ofFoods (Basel, Switzerland) · 2025Article
- Exploring Spent Coffee Grounds: Comprehensive Morphological Analysis and Chemical Characterization for Potential Uses.Molecules (Basel, Switzerland) · 2024Article
- Guidance on scientific principles and data requirements for the safety and relative bioavailability assessment of new micronutrient sources.EFSA journal. European Food Safety Authority · 2024Article
- Article
- A simulation study to improve calcium intake through wheat flour fortification.Public health nutrition · 2024Article
- Changes in the concentration of bone turnover markers in men after maximum intensity exercise.PeerJ · 2024Article
- Scientific and technical assistance to the evaluation of the safety of calcidiol monohydrate as a novel food.EFSA journal. European Food Safety Authority · 2024Article
- Genotoxicity evaluation of a fish oil concentrate containing Very Long Chain Fatty Acids.Toxicology reports · 2023Article
- Micronutrients in Food Supplements for Pregnant Women: European Health Claims Assessment.Nutrients · 2023Article
- Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate.EFSA journal. European Food Safety Authority · 2023Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to re-evaluate the safety in use of calcium. The Panel was requested to consider if the Tolerable Upper Intake Level (UL) for calcium established by the SCF in 2003 (2,500 mg/day for adults, including pregnant and lactating women), which was based on different intervention studies of long duration in which total daily calcium intakes of 2,500 mg from both diet and supplements were tolerated without adverse effects, needed to be changed on the basis of new available evidence. A number of placebo controlled human intervention studies in adults published since then also showed that total daily calcium intakes of 2,500 mg from both diet and supplements are tolerated without adverse effects. The Panel considers that no relationship has been established between long-term calcium intakes from diet and supplements and increased risk of nephrolithiasis, cardiovascular disease or prostate cancer. No new data have become available which would require a revision of the UL for calcium for adults, including pregnant and lactating women, of 2,500 mg. No new data have become available which would allow the setting of a UL for infants, children or adolescents. Data from European populations indicate that intakes of calcium in high consumers among adult males can be close to the UL. Although available data do not allow the setting of a UL for infants, children or adolescents, no risk has been identified with highest current levels of calcium intake in these age groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.