ArticleEFSA journal. European Food Safety Authority2012
Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC).
Article in EFSA journal. European Food Safety Authority, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed.
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- AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project.Frontiers in public health · 2026Review
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- Safety assessment of the substance 2,2'-oxydiethylamine for use in plastic food contact materials.EFSA journal. European Food Safety Authority · 2024Article
- Guidance on the scientific requirements for an application for authorisation of a novel food in the context of Regulation (EU) 2015/2283.EFSA journal. European Food Safety Authority · 2024Article
- Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products.Environmental health : a global access science source · 2024Review
- Safety assessment of the substance amines, di-C14-C20-alkyl, oxidised, from hydrogenated vegetable oil, for use in food contact materials.EFSA journal. European Food Safety Authority · 2024Article
- Safety assessment of the substance calciumEFSA journal. European Food Safety Authority · 2024Article
- Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.Archives of toxicology · 2024Review
- A critical review of test methods and alternative scientific approaches to compliance and safety evaluation of paper and board for food contact.Frontiers in chemistry · 2024Review
- Guidance document on the impact of water treatment processes on residues of active substances or their metabolites in water abstracted for the production of drinking water.EFSA journal. European Food Safety Authority · 2023Article
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- Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data.Archives of toxicology · 2023Article
- Scientific Guidance on the data required for the risk assessment of flavourings to be used in or on foods.EFSA journal. European Food Safety Authority · 2022Article
- Developing an internal threshold of toxicological concern (iTTC).Journal of exposure science & environmental epidemiology · 2022Article
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- Focusing Points on FSCJ's Guideline Recently Established: Risk Assessment of Food Contact Materials.Food safety (Tokyo, Japan) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic and naturally occurring substances present in food and feed, together with their possible breakdown or reaction products, represent a large number of substances, many of which require risk assessment. EFSA's Scientific Committee was requested to evaluate the threshold of toxicological concern (TTC) approach as a tool for providing scientific advice about possible human health risks from low level exposures, its applicability to EFSA's work, and to advise on any additional data that might be needed to strengthen the underlying basis of the TTC approach. The Scientific Committee examined the published literature on the TTC approach, undertook its own analyses and commissioned an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.