ReviewInternational journal of molecular and cellular medicine2025
Regulation of Osteoblast Differentiation by miR-214 and miR-206 Through EphrinA2 Signaling: Emerging Therapeutic Insights in Orthodontic Tooth Movement.
Review in International journal of molecular and cellular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- MicroRNAs in periodontal disease: from pathogenic mechanisms and RANKL/OPG regulation to nanoparticle delivery and personalized medicine.Frontiers in immunology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthodontic tooth movement (OTM) is a complex biological process involving the precise remodeling of alveolar bone in response to mechanical forces. This remodeling is mediated by the coordinated activities of osteoblasts (responsible for bone formation) and osteoclasts (responsible for bone resorption) within the periodontal ligament (PDL). Mechanical stimuli are transduced into biochemical signals, which regulate cellular behavior through key signaling pathways such as RANKL/RANK/OPG and Wnt/β-catenin. MicroRNAs (miRNAs), as crucial post-transcriptional regulators of gene expression, play significant roles in skeletal development and bone homeostasis. They influence essential signaling cascades that govern the differentiation, function, and survival of osteoblasts and osteoclasts. Among them, miR-214 and miR-206 have emerged as potent negative regulators of osteoblast differentiation. This review focuses on how their common target, EphrinA2, plays a pivotal role in bone remodeling. EphrinA2 is a membrane-bound ligand critical for osteoclast-osteoblast communication. Upon binding to its receptor EphA2 on osteoblasts, EphrinA2 promotes osteoblast differentiation and bone formation. Dysregulation of the miR-214/miR-206-EphrinA2 axis impairs osteoblast function, disrupts bone remodeling, and can adversely affect the rate and stability of OTM. In conclusion, elucidating the regulatory functions of miR-214 and miR-206 and their modulation of EphrinA2 provides valuable insights into bone remodeling dynamics during OTM. Targeted manipulation of this pathway holds promise for developing novel molecular therapies that aim to enhance the efficacy, speed, and long-term stability of orthodontic treatments, while also addressing broader skeletal pathologies associated with disrupted bone remodeling.
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Registered trials
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