ArticleInternational journal of endocrinology2026
Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study.
Article in International journal of endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study.International journal of endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sex hormones have been associated with the risk of hyperuricemia (HUA) and gout in observational studies, but the potential causal relationships between sex hormones and risk of HUA and gout remain largely unclear. This study aimed to further investigate the mechanism underlying the causality between sex hormones, HUA, and gout in different genders. Methods: We used sex-specific genome-wide association study (GWAS) data for European populations. The genetic correlation between sex hormones and serum urate or gout was analyzed using linkage disequilibrium score regression (LDSC). Two-sample Mendelian randomization (MR) analysis assessed the causality between sex hormones (total testosterone [ToT], bioavailable testosterone [BioT], SHBG, estradiol, age at menarche, and age at menopause) and serum urate or gout, followed by sex-stratified analysis. Colocalization analysis examined shared genetic variants between sex hormones and outcomes. Sensitivity analyses were additionally performed to address potential pleiotropy. A two-step MR was conducted to evaluate the mediation effects of circulating metabolites linking sex hormones with serum urate. Results: Genetic correlation analysis revealed moderate associations between sex hormones and serum urate/gout. MR analysis indicated a significant association between genetically predicted ToT and increased serum urate levels among women ( Conclusions: These findings provide robust evidence that sex hormones influence urate metabolism with significant sex-specific differences, suggesting tailored interventions for HUA, especially in European women with hyperandrogenism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.