Evidence map›Paper›PMID 42015892›Full record

ArticleJNCI cancer spectrum2026

The microbiome landscape of oral cancer in young patients.

Laveniya Satgunaseelan, Dario Strbenac, Carsten Palme, Tsu-Hui Hubert Low, James Wykes, Tim Manzie, Jonathan R Clark, Jean Y H Yang, Ruta Gupta

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In one paragraph

Article in JNCI cancer spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Laveniya SatgunaseelanDepartment of Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, Sydney, Australia.ORCID 0000-0002-7435-0834
Dario StrbenacSchool of Mathematics and Statistics, The University of Sydney, Sydney, Australia.
Carsten PalmeDepartment of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Chris O'Brien Lifehouse, Sydney, Australia.
Tsu-Hui Hubert LowFaculty of Medicine and Health Sciences, Sydney Medical School, The University of Sydney, Sydney, Australia.ORCID 0000-0001-8958-736X
James WykesFaculty of Medicine and Health Sciences, Sydney Medical School, The University of Sydney, Sydney, Australia.ORCID 0000-0002-2956-0453
Tim ManzieFaculty of Medicine and Health Sciences, Sydney Medical School, The University of Sydney, Sydney, Australia.ORCID 0000-0001-9171-9878
Jonathan R ClarkFaculty of Medicine and Health Sciences, Sydney Medical School, The University of Sydney, Sydney, Australia.ORCID 0000-0003-1209-772X
Jean Y H YangSchool of Mathematics and Statistics, The University of Sydney, Sydney, Australia.ORCID 0000-0002-5271-2603
Ruta GuptaDepartment of Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, Sydney, Australia.ORCID 0000-0003-2940-313X

Funding

Cancer Institute New South Wales 2020/2081National Health and Medical Research Council 2024602Office of Health and Medical Research H20/113193Sydney Local Health District; the Walker Family Foundation
6 · The paper itself

Abstract

backgroundThe incidence of oral squamous cell carcinoma (OSCC) is rising in patients under the age of 50, without smoking or alcohol abuse. Viruses are not a causative factor of OSCC in younger patients. The oral microbiome has not been evaluated in this unique patient cohort for a potential bacterial etiology.

methodsWe report the bacterial diversity and composition of the largest cohort of OSCC patients with whole genome sequencing (n = 72) and compare it with oral mucosa from healthy controls (n = 10) using the Strengthening the Organization and Reporting of Microbiome Studies guidelines.

resultsThe microbial diversity between tumor, normal mucosa from cancer patients and healthy control mucosa is significantly different, with specific species (Streptococcus mitis, Haemophilus haemolyticus, and Cutibacterium acnes) reduced in normal mucosa of cancer patients as compared with healthy controls (adjusted P < .05). The microbial diversity is significantly higher in younger patients as compared with older patients (P < .001), with a reduced abundance of anaerobes in older patients (Aggregatibacter segnis, Gemella morbillorum, Peptostreptococcus stomatis, Filifactor alocis, and Porphyromonas endodontalis; adjusted P < .05). CONCLUSION(S): The OSCC tissue of younger patients is significantly more polymicrobial, and their OSCC microbiomes harbor more anaerobic bacteria as compared with older patients. This compositional difference builds the hypothesis that the oral microbiome of younger OSCC patients may have a more hypoxic, immunosuppressive tumor microenvironment with its associated implications for treatment resistance and a potential link to baseline poor dentition.

Indexed as

Carcinoma, Squamous CellMicrobiotaMouth MucosaMouth NeoplasmsAdultAgedAge FactorsBacteria, AnaerobicCase-Control StudiesFemaleHumansMaleMiddle AgedPeptostreptococcusalpha diversitybeta diversityearly onset cancermicrobiomeoral squamous cell carcinoma

Identifiers

PMID42015892
PMCPMC13124277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.