Evidence map›Paper›PMID 42015889›Full record

Trial reportThe oncologist2026

Real-world feasibility and effectiveness of a personalized exercise program during cancer treatment: results from the CHOiCE prospective study.

Alice Avancini, Anita Borsati, Gloria Adamoli, Linda Toniolo, Christian Ciurnelli, Andrea Trevisan, Lorenzo Belluomini, Ilaria Trestini, Daniela Tregnago, Marco Sposito and 8 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The oncologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04226508 (Different Modalities of Exercise for Physical Activity Promotion in Cancer Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04226508 naunknown statusnot on this map

Different Modalities of Exercise for Physical Activity Promotion in Cancer Patients

TypeinterventionalSponsorUniversita di VeronaRan2019 to 2024Enrolled80ConditionsMixed CancerArmsPhysical exercise
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alice AvanciniSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.ORCID 0000-0003-2439-4799
Anita BorsatiDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.ORCID 0000-0002-6898-091X
Gloria AdamoliDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.
Linda TonioloDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.
Christian CiurnelliDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.
Andrea TrevisanDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.
Lorenzo BelluominiSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.
Ilaria TrestiniDietetic Service, Medical Direction, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, 37134, Italy.
Daniela TregnagoSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.
Marco SpositoSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.
Jessica InsoldaSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.
Stefano ManducaSection of Oncology, University of Verona Hospital Trust (AOUI), Verona, 37134, Italy.
Alessandra AuriemmaSection of Oncology, University of Verona Hospital Trust (AOUI), Verona, 37134, Italy.
Elena FiorioSection of Oncology, University of Verona Hospital Trust (AOUI), Verona, 37134, Italy.
Michele MilellaSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.
Massimo LanzaDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.ORCID 0000-0001-9091-6589
Federico SchenaDepartment of Neurosciences, Biomedicine and Movement, University of Verona, Verona, 37134, Italy.
Sara PilottoSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, and University and Hospital Trust (AOUI) of Verona, Verona, 37134, Italy.ORCID 0000-0003-2229-4874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite strong evidence supporting exercise in oncology, real-world data on its feasibility and effectiveness across cancer types remain limited. The CHOiCE (Choose Health: Oncological patients Centered Exercise) study aimed to evaluate a flexible, patient-centered exercise program in routine clinical practice. MATERIALS AND

methodsThis prospective cohort study enrolled 180 adult patients undergoing treatments. Participants completed a 12-week program combining aerobic and resistance training, delivered in person, at home, or hybrid. Primary outcomes were recruitment rate, adherence, dropout, and safety. Secondary outcomes included physical fitness, quality of life, and physical activity. Subgroup analyses explored responses by cancer type, stage, treatment, and delivery mode.

resultsRecruitment rate was 82%, with a median attendance of 88%. The dropout rate was 32%, mainly due to personal reasons or disease progression. No serious adverse events were reported. Significant improvements were observed in the six-minute walk test (+39 m, P < .001), leg press strength (+7.1 kg, P < .001), handgrip strength (+1.0 kg, P = .003), and flexibility tests (P < .05). Quality of life improved in physical, role, emotional, and social functioning. Fatigue, nausea, dyspnea, insomnia, and appetite loss were significantly reduced. Patients with gastrointestinal cancer, stage III-IV disease, or undergoing chemotherapy showed the largest gains.

conclusionA patient-centered exercise program for patients with cancer is feasible and effective in a real-world setting. These findings support integrating tailored exercise into routine oncology care.

trial registrationNCT04226508.

Indexed as

ExerciseExercise TherapyNeoplasmsAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPhysical FitnessProspective StudiesQuality of Lifephysical exercisephysical fitnessquality of lifereal-world settingtailored intervention

Identifiers

PMID42015889
PMCPMC13153686

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.