Evidence map›Paper›PMID 42015770›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Acupuncture inhibits astrocytic hyperactivationthe p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1 signaling pathway in cerebral ischemia-reperfusion injury.

Zhuang Zifeng, W O Choying, Chen Hongling, Xie Hailiang, Zhao Canghuan, Zhang Di, Qing Peng

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhuang ZifengCollege of Traditional Chinese Medicine,Jinan University,Guangzhou510632,China.
W O ChoyingCollege of Traditional Chinese Medicine,Jinan University,Guangzhou510632,China.
Chen HonglingCollege of Traditional Chinese Medicine,Jinan University,Guangzhou510632,China.
Xie HailiangDepartment of Acupuncture,the First Affiliated Hospital of Jinan University,Guangzhou510630,China.
Zhao CanghuanDepartment of Acupuncture,the First Affiliated Hospital of Jinan University,Guangzhou510630,China.
Zhang DiCollege of Traditional Chinese Medicine,Jinan University,Guangzhou510632,China.
Qing PengDepartment of Acupuncture,the First Affiliated Hospital of Jinan University,Guangzhou510630,China.

Funding

China Postdoctoral Science Foundation General Funding: Danggui Sini Decoction Promotes Damaged Nerve Repair and Treats Sciatica by Modulating Endothelial Cell-schwann Cell Coupling 2024M751136China Postdoctoral Science Foundation Special Funding (Pre-Station): Danggui Sini Decoction Inhibits Peripheral Sensitization and Alleviates Sciatica by Regulating Macrophage-neuron Crosstalk 2023TQ0135Guangdong Basic and Applied Basic Research Foundation: Danggui Sini Decoction Promotes Damaged Nerve Repair and Treats Sciatica by Inhibiting Secreted Phosphoprotein 1/Cluster of Differentiation 44-Mediated Macrophage-Schwann Cell Crosstalk 2025A1515011267Guangzhou Basic and Applied Basic Research Foundation: Mechanistic Investigation of Ziwu Liuzhu Acupuncture for Insomnia Based on the Heat Shock Protein 90/Stimulator of Interferon Genes-nuclear Factor Kappa B Immune Pathway and Its Regulation of Sleep-Wake Rhythms 2025A03J3400Guangzhou Doctoral Start-up Program: Danggui Sini Decoction Regulates Angiopoietin-like 4/Syndecan-4-mediated Neurovascular Coupling to Promote Injured Nerve Repair for the Treatment of Sciatica 2025A04J3397National Natural Science Foundation of China (Youth Program): Investigation of Danggui Sini Decoction in Improving Neuro-microcirculation and Promoting Nerve Repair for the Treatment of Sciatica Based on Angptl4/Sdc4-mediated Endothelial Cell-Schwann Cell Coupling 82405081
6 · The paper itself

Abstract

objectiveTo observe the effect of acupuncture on astrocyte activation following cerebral ischemia-reperfusion injury (CIRI)

methodsTranscriptome and single-cell sequencing were used to analyse gene expression in middle cerebral artery occlusion (MCAO)-induced rats. Acupuncture was applied at Baihui (GV20) and Dazhui (GV14) for 7 d. The infarct volume was assessed

resultsCIRI activated p38 MAPK signaling, increased the expression of A1 markers (GFAP and C3), and proinflammatory cytokines, and decreased the expression of the A2 marker S100A10. Acupuncture inhibited p38 phosphorylation, upregulated MSK1, reduced C3 and inflammatory cytokines, increased S100A10 expression, decreased infarct volume, and improved neurological function.

conclusionAcupuncture protects against ischemic stroke by targeting the p38 MAPK/MSK1 pathway. It inhibits p38 MAPK phosphorylation and activates MSK1, thereby promoting a shift in astrocyte polarization from the pro-inflammatory A1 to the reparative A2 type, as reflected by decreased C3 and increased S100A10 expression. This shift reduces pro-inflammatory cytokines, alleviates cerebral inflammation, and promotes neural repair, ultimately diminishing infarct volume, restoring neurons, and improving behavior. These findings elucidate the mechanism of acupuncture and support its clinical use.

Indexed as

Acupuncture TherapyAstrocytesBrain Ischemiap38 Mitogen-Activated Protein KinasesReperfusion InjuryRibosomal Protein S6 Kinases, 90-kDaAnimalsHumansInterleukin-1betaInterleukin-6MaleRatsRats, Sprague-DawleySignal TransductionTumor Necrosis Factor-alphaInterleukin-1betaInterleukin-6mitogen and stress-activated protein kinase 1p38 Mitogen-Activated Protein KinasesRibosomal Protein S6 Kinases, 90-kDaTumor Necrosis Factor-alphaacupunctureastrocytescerebral ischemia-reperfusion injuryinflammatory responsep38 mitogen-activated protein kinasestroke

Identifiers

PMID42015770
PMCPMC13077117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.