ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Xiaotan Sanjie recipe suppressed the oncogenic potential of cancer-associated fibroblaststhe stromal-derived factor 1α/C-X-C chemokine receptor type 4 pathway in gastric cancer.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the impact and mechanism of action of Xiaotan Sanjie (, XTSJ) on the invasiveness and metastasis of gastric cancer (GC) by modulating cancer-associated fibroblasts (CAFs). MKN-45 cells were used in
methodsTwo types of fibroblasts, CAFs and normal fibroblasts, were isolated from the tissue sample of two patients following GC surgery. The
resultsThe results indicated that CAFs significantly enhance the migration and invasion of GC cells compared to NFs. However, following treatment with XTSJ, CAF's ability to promote GC was reduced. XTSJ treatment significantly inhibited CAF proliferation and downregulated the expression of CAF-associated cytokines IL-1β, IL-6, VEGF, and SDF-1α. The SDF-1α/ CXCR4 signaling pathway is a potential key mechanism through which CAFs impact GC invasion.
conclusionXTSJ treatment inhibited tumor-promoting capabilities in CAFs, suppressing GC progression, invasion, and metastasis. This study offers empirical support for the potential clinical application of XTSJ in treating and preventing GC metastasis.
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