ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Qianyang Yuyin granule modulates glycolysis and inflammatory response to treat hypertensive cardiac remodeling.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the effect of Qianyang Yuyin granule (QYYY) on AngII-induced hypertensive cardiac remodeling, focusing on the role of pyruvate kinase isozyme M2 (PKM2) mediated glycolysis.
methodsA hypertensive mouse model was established in male C57BL/6 mice by continuous infusion of angiotensin II (AngII; 1000 ng·kg
resultsQYYY significantly lowered blood pressure, attenuated cardiac hypertrophy and fibrosis, reduced serum levels of inflammatory factors tumor necrosis factor-α and tumor necrosis factor-β, and decreased activation of phospho-NF-kappa B p65 pathway in cardiac tissue of hypertensive mice. Metabolomic analysis indicated that QYYY ameliorated cardiometabolic dysfunction, primarily associated with energy and amino acid metabolism, involving modulation of the HIF-1α/PKM2-mediated glycolytic pathway.
conclusionQYYY effectively improves cardiac remodeling in hypertensive mice, potentially through inhibition of the PKM2-mediated glycolytic signaling pathway.
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