ReviewFuture science OA2026
Ginger-derived nanoparticles targeting NF-κB mediated inflammatory pathways: a systematic review of in vitro and in vivo evidence.
Review in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Targeting Folate Receptors for the Detection and Selective Treatment of Cancer: Advanced Precision Oncology in Practice.International journal of biological sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNuclear factor kappa B (NF-κB) is a key regulator of inflammatory responses involved in chronic inflammatory diseases. Bioactive compounds from ginger (
methodsEligible studies included peer-reviewed English preclinical in vitro and in vivo studies assessing ginger-derived nanoparticles targeting NF-κB mediated inflammation; reviews, clinical studies, and non-nanoparticle ginger formulations were excluded. Databases searched were PubMed, ScienceDirect, SpringerLink, the Cochrane Library, Scopus, Web of Science, and Embase (January 2010 to August 2025). Risk of bias was assessed using SYRCLE, SciRAP, and MISEV 2018 tools, and findings were narratively synthesized due to methodological heterogeneity.
resultsSeven preclinical studies were included. Ginger-derived nanoparticles consistently suppressed canonical NF-κB signaling by inhibiting IκBα phosphorylation and p65 nuclear translocation, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), oxidative stress, and tissue inflammation. Evidence was limited by small study numbers, heterogeneous nanoparticle formulations, and reliance on preclinical data, preventing meta-analysis.
conclusionGinger-derived nanoparticles represent a promising experimental strategy for modulating inflammatory signaling pathways in preclinical models. PROTOCOL REGISTRATION: PROSPERO (CRD420261337393).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.