Evidence map›Paper›PMID 42015580›Full record

ReviewPest management science2026

RNA interference in crop protection: opportunities and challenges during the transition to commercialization.

Elisabetta Sergi, Anna Narduzzo, Alessandra Di Canito, Francesco Favaretto, Luca Nerva, Walter Chitarra, Lucia Bologna, Jacopo Bacenetti, Giuliana Maddalena, Simona Masiero and 3 more

Abstract readReview
In one paragraph

Review in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Advances in the Control of Plant Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisabetta Sergi *Department of Agricultural and Environmental Sciences (DiSAA), University of Milan, Milan, Italy.
Anna Narduzzo *Council for Agricultural Research and Economics - Research Centre for Viticulture and Enology, Conegliano, Italy.
Alessandra Di Canito *Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Francesco FavarettoCouncil for Agricultural Research and Economics - Research Centre for Viticulture and Enology, Conegliano, Italy.
Luca NervaCouncil for Agricultural Research and Economics - Research Centre for Viticulture and Enology, Conegliano, Italy.ORCID https://orcid.org/0000-0001-5009-5798
Walter ChitarraCouncil for Agricultural Research and Economics - Research Centre for Viticulture and Enology, Conegliano, Italy.
Lucia BolognaDepartment of Agricultural and Environmental Sciences (DiSAA), University of Milan, Milan, Italy.
Jacopo BacenettiDepartment of Environmental Sciences and Policy (ESP), University of Milan, Milan, Italy.
Giuliana MaddalenaDepartment of Agricultural and Environmental Sciences (DiSAA), University of Milan, Milan, Italy.
Simona MasieroDepartment of Biosciences, University of Milan, Milan, Italy.
Ileana VigentiniDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Gabriella De LorenzisDepartment of Agricultural and Environmental Sciences (DiSAA), University of Milan, Milan, Italy.
Silvia Laura ToffolattiDepartment of Agricultural and Environmental Sciences (DiSAA), University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0003-3572-8686

Funding

Grape4vine-recycling grape wastes to protect grapevine from fungal pathogens 2022-0617Italian Ministry of University and Research (MUR) PRIN 2022SMARTBERRY - Smart Biotechnology for Sustainable Berry Cultivation 2022BE543BSMARTBERRY - Smart Biotechnology for Sustainable Berry Cultivation CUP G53D23003960006
6 · The paper itself

Abstract

RNA interference (RNAi) has emerged as a promising tool for crop protection, offering the potential for high specificity and the ability to target a wide range of pests and pathogens through sequence-specific design. Growing interest from academia has accelerated research in the field, while some companies have seized the opportunity to develop RNAi-based products in regulatory environments more open to this type of innovation, positioning RNAi as a potential alternative or complement to conventional plant protection products. Notably, the recent registration of double-stranded RNA (dsRNA)-based products for insect control marks a transition from experimental research to early commercialization. However, several challenges remain before widespread adoption, especially in Europe. These include regulatory uncertainties, high production costs of dsRNA (used to trigger RNAi), limited comparative field efficacy data, and societal concerns related to emerging biotechnologies. Furthermore, broader validation is needed for environmental risk assessment. Despite these obstacles, RNAi has strong potential to enhance crop protection under climate change and delay resistance, especially when integrated with other technologies. Continued research, cost-effective production methods, and strong collaborations between academia, industry and regulators are essential to support responsible implementation, potentially improving access to advanced plant protection tools for smallholders and vulnerable farming communities. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Crop ProtectionCrops, AgriculturalInsect ControlPest Control, BiologicalRNA InterferenceAnimalsRNA, Double-StrandedRNA, Double-Strandedagricultural biotechnologydisease controlHIGS (host‐induced gene silencing)plant protectionSIGS (spray‐induced gene silencing)sustainable agriculture

Identifiers

PMID42015580
PMCPMC13240698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.