ArticleBrain and behavior2026
Therapeutic Potential of Select Berry Varieties in Mitigating Cognitive Decline via Oxidative Stress and Insulin Resistance in AlCl
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOxidative stress damage and impaired insulin receptor (IR) signaling are critical risk factors for contributing to cognitive impairment in Alzheimer's disease (AD) and other neurological disorders. The beta-amyloid peptide (Aβ) oligomer deposition in the hippocampal region decreases the IR expression. This study aimed to assess whether berries grown in Oman (Morus alba, Morus macroura, and Sideroxylon mascatense) could ameliorate dysfunction of the antioxidant system and restore the IR expression thereby improve the cognitive performance in aluminum chloride (AlCl
methodsVarious biochemical assays were conducted to estimate antioxidant capacity. The total phenolic (TPC) and flavonoid (TFC) contents for the three varieties were quantified using Folin-Ciocalteu and AlCl
findingsBerries, particularly M. alba and S. mascatense, demonstrated the highest phenolic and flavonoid content and exhibited strong antioxidant activity across all assays. Mice fed with M. alba, M. macroura, and S. mascatense showed better performance parameters in both MWM (spatial learning and memory) and T-maze (time taken to reach the platform) tests, along with enhanced IR signaling (p < 0.01).
conclusionThese findings suggest that supplementation with mulberries may improve cognitive decline and insulin resistance induced by AlCl
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.