Evidence map›Paper›PMID 42015354›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Integrating the physical environment into Alzheimer's disease and Alzheimer's disease related dementias research: A Gateway Exposome Coordinating Center (GECC) agenda on gaps and priorities.

Dany Doiron, Zorana Jovanovic Andersen, Matthew Bozigar, Rima Habre, Perry Hystad, Ingrid Jarvis, David Knapp, Tom J Luben, Priya Patel, Jayant M Pinto and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Dany DoironDepartment of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montréal, Québec, Canada.
Zorana Jovanovic AndersenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Matthew BozigarSchool of Nutrition and Public Health, Oregon State University, Corvallis, Oregon, USA.
Rima HabreKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Perry HystadSchool of Nutrition and Public Health, Oregon State University, Corvallis, Oregon, USA.
Ingrid JarvisSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
David KnappCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Tom J LubenSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Priya PatelDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Jayant M PintoSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, Illinois, USA.
Beate RitzSchool of Public Health, Environmental Health Department, University of California, Los Angeles, Los Angeles, California, USA.
John VolckensDepartment of Mechanical Engineering, Colorado State University, Fort Collins, Colorado, USA.
Gregory A WelleniusCenter for Climate and Health and Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Jinkook LeeCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Michael BrauerSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Jeffrey BrookDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Sara D AdarSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Gateway Exposome Coordinating Center (GECC) For AD/ADRD ResearchU24AG088894 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, David Michael Keith Knapp · 2024 to 2026
$14.8M
NEXUS: Network for Exposomics in the U.S.U24ES036819 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rima Habre, GARY W MILLER · 2024 to 2026
$4.6M
NIA NIH HHS U24 AG088894NIA NIH HHS U24AG088894NIEHS NIH HHS U24 ES036819
6 · The paper itself

Abstract

The physical environment is an important yet underexplored domain in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD), shaping exposures and health-related behaviors across the life course. We identified key gaps and priorities for incorporating physical environment measures into population-based research, with an emphasis on geospatial data that can be applied in large cohorts and administrative datasets. The Gateway Exposome Coordinating Center (GECC) synthesized input from six town halls, a 4-day expert workshop, and the literature to build consensus on priority physical environment exposures and a roadmap for advancing exposure data. We also identified four methodological imperatives: developing pathway-relevant metrics, addressing temporality, incorporating behavior into exposure estimation, and integrating co-occurring exposures. Advancing guidance and exposure metrics in these areas can support prevention-oriented, policy-relevant research and improve understanding of how physical environments influence brain health.

Indexed as

Alzheimer DiseaseDementiaEnvironmental ExposureExposomeBrainEnvironmentEvidence GapsHumansair pollutionAlzheimer's disease and related dementiascommunity amenitiesenvironmental epidemiologyexposomegeospatial exposure assessmentgreenspacelife‐course exposurenoisephysical environmentspatial epidemiologyurban form

Identifiers

PMID42015354
PMCPMC13099584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.