ArticleGenome biology2026
SpaNiche: spatial niche analysis to explore colocalization patterns and cellular interactions in spatial transcriptomics data.
Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies.Molecular cancer · 2026Review
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7 authors.
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Abstract
We propose a computational framework for spatial niche analysis (SpaNiche) in spatial transcriptomics data to uncover colocalization patterns and infer potential ligand-receptor interactions. SpaNiche leverages graph-regularized joint non-negative matrix factorization to integrate information from cell abundance and ligand-receptor expression, identifying spatial colocalization patterns among cell types while providing insights into associated ligand-receptor interactions. Besides, SpaNiche employs consensus clustering to define "ecotypes", enhancing its utility in multi-sample spatial transcriptomics datasets. We investigate microenvironmental ecotypes in colorectal cancer, prostate cancer and cerebral cortex in early Alzheimer's disease, highlighting the broad applicability in dissecting complex colocalization patterns within spatial tissue microenvironments.
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