ArticleBMC medical informatics and decision making2026
Development and validation of the ANGS score for predicting long-term outcomes in acute ischemic stroke patients receiving intravenous thrombolysis.
Article in BMC medical informatics and decision making, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Predicting stroke-associated pneumonia for acute ischemic stroke patients post intravenous thrombolysis: the post-IVT-SAP risk score.Frontiers in medicine · 2026Article
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10 authors.
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Abstract
purposeTo develop and validate a weighted predictive scoring system for identifying poor long-term functional outcomes in acute ischemic stroke (AIS) patients undergoing intravenous thrombolysis (IVT) therapy.
methodsIn this study, we initially conducted a retrospective analysis of a derivation cohort comprising 555 consecutive AIS patients who received IVT treatment. Through multivariable logistic regression analysis, we identified independent predictors of 90-day functional outcomes, which were subsequently utilized to develop a predictive scoring tool (ANGS score). To evaluate its clinical applicability, we performed both retrospective and prospective validations of the ANGS score in independent cohorts.
resultsThe ANGS score was derived based on four key variables: age, the National Institutes of Health Stroke Scale (NIHSS) score, blood glucose on admission (Glu), and systolic blood pressure (SBP). The model demonstrated strong discriminative capacity across all cohorts, achieving AUC values of 0.803 in the derivation cohort, 0.837 in the retrospective validation cohort (Validation 1), and 0.789 in the prospective validation cohort (Validation 2) for long-term functional outcome prediction. The ANGS score consistently demonstrated as an important predictor of 90-day outcomes in the derivation cohort. Logistic regression analysis revealed a strong, statistically significant association between increasing ANGS scores and poor 90-day mRS outcomes (OR = 3.243, 95% CI: 2.639–3.984; P < 0.001).
conclusionThe ANGS score represents a clinically practical and reliable tool for predicting long-term functional outcomes in AIS patients following IVT therapy. This scoring system may enhance clinical decision-making processes and provide valuable prognostic information for healthcare providers, patients, and their families.
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