Evidence map›Paper›PMID 42014962›Full record

ArticleThe American journal of psychiatry2026

Transcriptional Profiles of Somatostatin and Parvalbumin Interneuron Subtypes in the Human Dorsolateral Prefrontal Cortex: Implications for Schizophrenia.

John F Enwright, Alex M Tamburino, Tayfun Tumkaya, Ditte Lovatt, Jie Pan, Ramesh Gunaratna, Delphine Fagegaltier, Xiaohai Wang, Michael J Marino, Ken Fish and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

John F EnwrightDepartment of Psychiatry, University of Pittsburgh, Pittsburgh.
Alex M TamburinoSpatial and Single Cell Multiomics Data, AI & Genome Sciences, Merck & Co, Inc., Cambridge, MA.
Tayfun TumkayaEarly Discovery Genetics, Merck & Co, Inc., Cambridge, MA.
Ditte LovattNeuroscience, Merck & Co, Inc., West Point, PA.
Jie PanNeuroscience, Merck & Co, Inc., West Point, PA.
Ramesh GunaratnaNeuroscience, Merck & Co, Inc., West Point, PA.
Delphine FagegaltierEarly Discovery Genetics, Merck & Co, Inc., Cambridge, MA.
Xiaohai WangNeuroscience, Merck & Co, Inc., West Point, PA.
Michael J MarinoNeuroscience, Merck & Co, Inc., West Point, PA.
Ken FishDepartment of Psychiatry, University of Pittsburgh, Pittsburgh.
Dominique ArionDepartment of Psychiatry, University of Pittsburgh, Pittsburgh.
Guillermo Gonzalez-BurgosDepartment of Psychiatry, University of Pittsburgh, Pittsburgh.
David A LewisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh.

Funding

SCHIZOPHRENIA AND CORTICAL DOPAMINE/GABA INTERACTIONSR01MH043784 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEWIS, DAVID A · 1988 to 2023
$7.2M
GABA Neurons and Cortical Circuitry in SchizophreniaR37MH043784 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEWIS, DAVID A · 2001 to 2010
$6.8M
Deciphering the GABA neuron alterations in schizophreniaR01MH119701 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N · 2019 to 2023
$2.2M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
Request for an Olympus VS200 slide scannerS10MH126905 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N, WATKINS, SIMON C · 2021 to 2021
$370k
NIH HHS S10 OD028483NIMH NIH HHS R01 MH043784NIMH NIH HHS R01 MH119701NIMH NIH HHS R37 MH043784NIMH NIH HHS S10 MH126905
6 · The paper itself

Abstract

objectiveAlterations in the somatostatin (

methodsThe authors used single-nucleus RNA sequencing to determine the transcriptional profiles of interneuron subtypes in DLPFC tissue samples from discovery and validation cohorts; fluorescent in situ hybridization to validate selected findings; and comparisons of transcriptome and electrophysiology data from the Allen Brain Atlas to infer functional properties of selected subtypes.

resultsThe relative proportions of five major interneuron classes and of 37 interneuron subtypes were highly consistent across 19 individuals. Eleven

conclusionsThe robust identification of discrete subtypes of

Indexed as

Dorsolateral Prefrontal CortexInterneuronsParvalbuminsPrefrontal CortexSchizophreniaSomatostatinAdultFemaleHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedTranscriptomeYoung AdultParvalbuminsSomatostatinSST protein, humanCognition/Learning/MemoryNeuroscienceSchizophrenia Spectrum and Other Psychotic Disorders

Identifiers

PMID42014962
PMCPMC13397501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.