Evidence map›Paper›PMID 42014936›Full record

ArticleACS chemical biology2026

Targeting a Unique Cysteine Residue to Achieve Isoform-Selective Inhibition of the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 2.

Tyrell C Rossman, Kaylen R Meeks, Gunjan Purohit, Michael J Naldrett, John J Tanner, Donald F Becker

Abstract read
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tyrell C RossmanDepartment of Biochemistry, Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, United States.
Kaylen R MeeksDepartment of Biochemistry, University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0001-9024-6255
Gunjan PurohitDepartment of Biochemistry, Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, United States.
Michael J NaldrettProteomics and Metabolomics Facility, Nebraska Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.ORCID 0000-0002-6899-5652
John J TannerDepartments of Biochemistry and Chemistry, University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0001-8314-113X
Donald F BeckerDepartment of Biochemistry, Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, United States.ORCID 0000-0002-1350-7201

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Investigating the Proline Cycle as a Potential Cancer Therapy TargetR01GM132640 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2020 to 2026
$1.9M
Molecular Mechanisms of DiseaseT32GM136593 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Donald F Becker, EDWARD N HARRIS · 2020 to 2026
$1.8M
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM132640NIGMS NIH HHS T32 GM136593
6 · The paper itself

Abstract

Proline metabolism is selectively altered in cancer cells, providing ATP, redox balance, and proline for cell growth. The final enzyme of proline biosynthesis is Δ

Indexed as

CysteineEnzyme InhibitorsProlinePyrroline Carboxylate ReductasesAzolesdelta-1-Pyrroline-5-Carboxylate ReductaseHumansIsoenzymesIsoindolesOrganoselenium CompoundsAzolesCysteinedelta-1-Pyrroline-5-Carboxylate ReductaseebselenEnzyme InhibitorsIsoenzymesIsoindolesOrganoselenium CompoundsProlinePyrroline Carboxylate Reductases

Identifiers

PMID42014936
PMCPMC13307452

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.