ReviewNature neuroscience2026
Genomic approaches for understanding the evolution of the human brain.
Review in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Human cognitive and social behaviors differ from those of other mammals, but the molecular, cellular and circuit-level changes that underlie these behavioral differences are poorly understood. The recent availability of thousands of mammalian, non-human primate, ancient human and modern human genomes now makes it possible to use quantitative approaches to identify genomic regions with signatures of selection in humans, which, when combined with comparative experimental approaches, can provide precise insights into the phenotypes that were the targets of adaptation across different evolutionary timescales. This Review presents a progress report on a 'genome-up' approach to understanding human brain evolution and lays out a framework for further advancement. Additional progress will require cohort expansion to improve the identification of genetic loci under selection, the application of comparative experimental approaches to additional milieus and the functional dissection of specific human-evolved loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.