Evidence map›Paper›PMID 42014757›Full record

ArticleNature communications2026

Zinc-redox crosstalk regulates proteostasis in the endoplasmic reticulum.

Yuta Amagai, Chihiro Arai, Wakana Yamamoto, Satoshi Watanabe, Toshiyuki Kowada, Roberto Sitia, Jun Hoseki, Shin Mizukami, Masaki Matsumoto, Kenji Inaba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuta AmagaiMedical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-2999-4622
Chihiro AraiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Miyagi, Japan.
Wakana YamamotoInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Miyagi, Japan.
Satoshi WatanabeMedical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID http://orcid.org/0000-0002-1130-0477
Toshiyuki KowadaInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Miyagi, Japan.ORCID http://orcid.org/0000-0002-6623-6505
Roberto SitiaDivision of Genetics and Cell Biology, Vita-Salute University, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID http://orcid.org/0000-0001-7086-4152
Jun HosekiDepartment of Applied Biological Sciences, Faculty of Bioenvironmental Science, Kyoto University of Advanced Science, Kameoka, Japan.
Shin MizukamiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Miyagi, Japan.
Masaki MatsumotoDepartment of Omics and Systems Biology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.ORCID http://orcid.org/0000-0002-6987-0288
Kenji InabaMedical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. kenji.inaba.a1@tohoku.ac.jp.ORCID http://orcid.org/0000-0001-8229-0467

Funding

Japan Agency for Medical Research and Development (AMED) 21gm1410006h0001Japan Society for the Promotion of Science London (JSPS London) 21H04758Japan Society for the Promotion of Science London (JSPS London) 21H05253Japan Society for the Promotion of Science London (JSPS London) 21K06060
6 · The paper itself

Abstract

Zinc homeostasis is crucial for various biological processes, including gene regulation, signal transduction, and proteostasis. ZIP7 is a membrane transporter that exports zinc ions (Zn

Indexed as

Endoplasmic ReticulumProteostasisZincCation Transport ProteinsEndoplasmic Reticulum StressGolgi ApparatusHomeostasisHumansMembrane GlycoproteinsMembrane ProteinsMolecular ChaperonesOxidation-ReductionProtein FoldingProteotoxic StressCation Transport ProteinsERP44 protein, humanMembrane GlycoproteinsMembrane ProteinsMolecular ChaperonesSLC39A7 protein, humanZinc

Identifiers

PMID42014757
PMCPMC13287676

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.