Evidence map›Paper›PMID 42014747›Full record

ArticleScientific reports2026

Impact of timely vaccination and genomic surveillance on controlling consecutive waves of SARS-CoV-2 variants.

Cecilia Salazar, Nídia S Trovão, Ignacio Ferrés, Alicia Costábile, Mercedes Paz, Paula Perbolianachis, Ana Moller, Viviana Bortagaray, Rodney Colina, Natalia Rego and 9 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Cecilia SalazarMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Nídia S TrovãoDivision of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Ignacio FerrésMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Alicia CostábileExperimental Virus Evolution Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Mercedes PazExperimental Virus Evolution Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Paula PerbolianachisExperimental Virus Evolution Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Ana MollerMolecular Virology Laboratory, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Viviana BortagarayMolecular Virology Laboratory, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Rodney ColinaMolecular Virology Laboratory, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Natalia RegoBioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Tamara Fernandez-CaleroBioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Lucia SpangenbergBioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Bernardina RiveraDiagnostic Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Martina AlonsoDiagnostic Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Matías MaidanaDiagnostic Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Interinstitutional Working Group
Gregorio IraolaMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay. goyo1987@gmail.com.
Gonzalo MoratorioExperimental Virus Evolution Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay. moratorio@pasteur.edu.uy.
Pilar MorenoExperimental Virus Evolution Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay. pmoreno@pasteur.edu.uy.

Funding

British Embassy Montevideo, Uruguay. International ProgrammeFOCEM COF 03/11Fondo de Solidaridad para Proyectos Innovadores, Sociedad Civil, Francofonía y Desarrollo Humano Ambassade de FranceG4 program, Institut Pasteur de Montevideo BSE
6 · The paper itself

Abstract

During the global COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOCs) emerged, causing massive transmission waves that affected infection outcomes, economies and public health. From January to July 2021 in Uruguay, the transmission wave was primarily driven by the Gamma VOC amidst a largely immunologically naive population. Following the implementation of a nationwide vaccination campaign, the detection of the Delta VOC in July 2021 did not trigger a significant transmission wave, even in the face of increased mobility during the winter holidays (late June to mid-July). We present a comprehensive analysis of the dynamics of SARS-CoV-2 in Uruguay until September 2021. By analysing 1792 viral genomes, we integrate genomic data with vaccination records, variant surveillance and epidemiological information at both regional and global scales. Our study highlights the role of timely vaccination combined with real-time genomic surveillance programmes in effectively monitoring and mitigating critical phases of the COVID-19 epidemic.

Indexed as

COVID-19COVID-19 VaccinesSARS-CoV-2VaccinationGenome, ViralGenomicsHumansPandemicsUruguayCOVID-19 VaccinesGenomic surveillanceSARS-CoV-2VaccinationVOCs

Identifiers

PMID42014747
PMCPMC13265770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.