Evidence map›Paper›PMID 42014711›Full record

ArticleNature communications2026

Performance improvement of single-molecule sensors through deep learning-based decoding of tunneling signals enables sub-attomolar sensitivity.

Xinhuan Zhang, Ziyang Wang, Ping Duan, Xijuan Wang, Yiming Chen, Yuxiao Chen, Manqiu Ma, Bailin Gao, Chuanxiang Chen, Zhichao Pan and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinhuan Zhang *School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.
Ziyang Wang *School of Artificial Intelligence, Guilin University of Electronic Technology, Guilin, PR China.ORCID http://orcid.org/0009-0000-5811-6493
Ping DuanCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin, PR China. duanping@nankai.edu.cn.
Xijuan WangSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.
Yiming ChenSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.
Yuxiao ChenSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.
Manqiu MaSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.
Bailin GaoSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.
Chuanxiang ChenSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China.ORCID http://orcid.org/0000-0001-9137-8356
Zhichao PanSchool of Artificial Intelligence, Guilin University of Electronic Technology, Guilin, PR China. panzhichao@guet.edu.cn.ORCID http://orcid.org/0000-0002-2858-0348
Chuancheng JiaCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin, PR China. jiacc@nankai.edu.cn.ORCID http://orcid.org/0000-0002-1513-8497
Saisai YuanSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, PR China. yuansaisai@just.edu.cn.ORCID http://orcid.org/0000-0001-9226-3753

Funding

China Postdoctoral Science Foundation 2023M741039China Postdoctoral Science Foundation 2025M771157National Natural Science Foundation of China (National Science Foundation of China) 22205084National Science Foundation of China | Key Programme 2024YFA1208100
6 · The paper itself

Abstract

Detecting individual molecules in real time provides high sensitivity for sensing applications. The break junction technique enables highly sensitive single-molecule detection by capturing the specific electronic signatures of individual molecules. However, this method is typically restricted by the requirement for anchoring groups on target analytes. Harnessing intermolecular interactions offers a solution to detect molecules without anchoring groups. Yet the resulting signals are often weak, sparse, and hidden in ensemble analyses. Here, we integrate rationally designed porphyrin-based probes with a time-frequency deep-learning framework to decode these subtle signatures. With this approach, we elevate the detection limit to the sub-attomolar level (10

Identifiers

PMID42014711
PMCPMC13287616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.