Evidence map›Paper›PMID 42014647›Full record

SynthesisInflammopharmacology2026

Clinical efficacy and mechanisms of krill oil supplementation in knee osteoarthritis: meta-analysis and mechanistic insights.

Haiyang Kou, Huaiquan Liu, Lingyan Lai, Shili Yang, Xinyan Zhang, Yu Sun, Yunling Xu, Bo Chen

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haiyang KouCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Huaiquan LiuCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Lingyan LaiCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Shili YangCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Xinyan ZhangCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Yu SunCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Yunling XuCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Bo ChenCollege of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China. dallastom@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the clinical efficacy and safety of krill oil supplementation in patients with knee osteoarthritis (KOA) through a systematic review and meta-analysis. Potential mechanisms are discussed based on existing literature.

methodsA systematic search was performed across PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials (RCTs) investigating krill oil supplementation in patients with KOA. Studies were selected according to pre-defined inclusion and exclusion criteria. Data were independently extracted by two reviewers and pooled using RevMan 5.4. Risk of bias was assessed with the Cochrane Risk of Bias tool.

resultsSix RCTs with 971 participants were included. Krill oil supplementation significantly improved pain and physical function (WOMAC scores at week 4), with moderate effects observed on stiffness. Krill oil significantly increased HDL-C and omega-3 levels, but had no effect on LDL-C and CRP. No significant adverse events were reported.

conclusionKrill oil is a promising functional food with a favorable safety profile for KOA symptom management, particularly for pain and physical function. The findings suggest potential mechanisms related to its anti-inflammatory and antioxidant effects, supporting its role in nutraceutical interventions for KOA.

Indexed as

Dietary SupplementsEuphausiaceaOilsOsteoarthritis, KneeAnimalsAnti-Inflammatory AgentsAntioxidantsHumansRandomized Controlled Trials as TopicTreatment OutcomeAnti-Inflammatory AgentsAntioxidantsOilsKnee osteoarthritisKrill oilMechanistic insightsMeta-analysisNutraceuticalsPain management

Identifiers

PMID42014647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.