Evidence map›Paper›PMID 42014594›Full record

ArticleJournal of natural medicines2026

Antioxidative effects of diarylheptanoids.

Sae Miyagishi, Yohei Saito, Masuo Goto, Kyoko Nakagawa-Goto

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sae MiyagishiSchool of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
Yohei SaitoSchool of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
Masuo GotoChemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599-7568, USA.
Kyoko Nakagawa-GotoSchool of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan. kngoto@p.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0002-1642-6538

Funding

Eshelman Institute for Innovation, University of North Carolina at Chapel Hill Eshelman Institute for Innovation, University of North Carolina at Chapel HillJapan Society for the Promotion of Science 25293024 and 25670054
6 · The paper itself

Abstract

Twenty-one diarylheptanoid derivatives including five symmetric and sixteen asymmetric, which were synthesized previously, evaluated for their antioxidant and antiproliferative activities. Among these, asymmetric diarylheptanoid 22 exhibited the most potent antioxidant effects. Compound 22 demonstrated a DPPH radical scavenging of 8.6 µM and, at a concentration of 100 µM, achieved 78.2% scavenging and 46.5% ferrous ion chelating activity. Combined with its relatively low toxicity against tested cell lines, 22 is a promising candidate for the treatment of diseases driven by oxidative stress.

Indexed as

AntioxidantsDiarylheptanoidsBiphenyl CompoundsCell Line, TumorHumansOxidative StressPicrates1,1-diphenyl-2-picrylhydrazylAntioxidantsBiphenyl CompoundsDiarylheptanoidsPicratesAntioxidantDiarylheptanoid

Identifiers

PMID42014594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.