ArticleNeotropical entomology2026
Mosquitocidal Activity and Enzyme Inhibition of Citrus sinensis Essential Oil Against Anopheles gambiae: In Vivo and In Silico Insights.
Article in Neotropical entomology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The growing resistance of Anopheles gambiae Giles, 1902 to synthetic insecticides poses a major challenge to malaria control, driving interest in botanical alternatives. This study assessed the mosquitocidal and enzyme-inhibitory potential of Citrus sinensis (L.) Osbeck, 1765 essential oil (CiSEO) and its primary constituents through in vivo bioassays and in silico analyses. Larvicidal and adulticidal activities were evaluated following World Health Organization (WHO) protocols, and biochemical assays measured acetylcholinesterase (AChE) and glutathione S-transferase (GST) inhibition, along with superoxide dismutase (SOD) and catalase (CAT) activities. Molecular docking and molecular dynamics (MD) simulations examined interactions with A. gambiae AChE and GST. CiSEO showed strong toxicity against larvae (LC
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