Evidence map›Paper›PMID 42014526›Full record

ArticleScientific reports2026

Relationships between cerebral blood flow and cognition in young adults born very preterm and at term.

Chandelle L Piazza, Vanessa Schmithorst, Claire E Kelly, Terrie E Inder, Lex W Doyle, Deanne K Thompson, Leona Pascoe, Michael Takagi, Peter J Anderson

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chandelle L PiazzaSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Victoria, Australia.
Vanessa SchmithorstDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
Claire E KellySchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Victoria, Australia.
Terrie E InderCenter for Perinatal and Infant Research, Rady Children's Health, Orange County, Orange, CA, USA.
Lex W DoyleClinical Sciences, Murdoch Children's Research Institute, Victoria, Australia.
Deanne K ThompsonSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Victoria, Australia.
Leona PascoeSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Victoria, Australia.
Michael TakagiSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Victoria, Australia.
Peter J AndersonSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Victoria, Australia. andersp3@hs.uci.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms underpinning persistent cognitive challenges in young adults born very preterm (VP; < 32 weeks' gestation) are unclear, but may include altered cerebral blood flow (CBF). We explored whether CBF differed between adults born VP and at term, and the associations between CBF and cognitive outcomes. Seventy-two participants born VP and 16 term-born controls born in Victoria, Australia, completed Arterial Spin Labelling-MRI and a neuropsychological assessment at 20 years of age. Using a voxel-wise general linear model, we analyzed CBF differences between VP and term-born individuals, and the relationships between CBF and cognitive outcomes. Adults born VP displayed lower CBF in several subcortical regions compared with their term-born peers. For both birth groups combined, CBF was positively associated with verbal delayed memory in frontal and temporal cortical regions, and negatively associated with executive functioning in frontal, temporal, occipital cortical regions and the cerebellum. Compared with the VP group, term-born adults exhibited stronger negative relationships between CBF and IQ, receptive language, and aspects of executive functioning. Few CBF-cognition relationships were observed in the VP group and when present, were positive. Overall, adults born VP exhibited lower CBF in subcortical regions with cortical CBF-cognition relationships in opposite directions across VP and term groups. These disparities may reflect cerebral dysmaturation in the VP group.

Indexed as

Cerebrovascular CirculationCognitionInfant, Extremely PrematureAdultFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaleNeuropsychological TestsYoung AdultASL-MRICerebral blood flowCognitionVery preterm

Identifiers

PMID42014526
PMCPMC13265763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.