Evidence map›Paper›PMID 42014405›Full record

ArticleNature communications2026

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration.

Ioana I N Da Silva, Desiree Ramirez, Sarah L Parylak, Leslie A Wallace, James K Tucker, Joel M Erberich, Rutvi Katariya, Aidan H McDonald, Iryna S Gallina, Ariana L Tucker and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Ioana I N Da SilvaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. ioana.ni@gmail.com.ORCID http://orcid.org/0000-0002-9486-2319
Desiree RamirezLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Sarah L ParylakLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Leslie A WallaceLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
James K TuckerLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Joel M ErberichLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Rutvi KatariyaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Aidan H McDonaldLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Iryna S GallinaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Ariana L TuckerLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Jillybeth BurgadoMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Baptiste N JaegerLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Jerika J BarronLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8983-3126
Joshua M PrattLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0009-0005-6989-5855
Monique PenaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Vipula RachaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Christina K LimLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Sarah FernandesLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Simone BenassiLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Lynne Randolph-MooreLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Krishna C VadodariaLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3455-0209
Maria C MarchettoLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Nicola J AllenMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7542-5930
Fred H GageLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. gage@salk.edu.ORCID http://orcid.org/0000-0002-0938-4106

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation plays a key role in Alzheimer's disease (AD) and many other neurodegenerative disorders. Chronic activation of astrocytes and microglia fuels neuronal damage via cytokine secretion, oxidative stress, and proteolysis, yet glial inflammatory regulation remains poorly understood. Using chemoproteomics, we identified CK2, particularly the brain-enriched catalytic subunit CK2α2, as a key driver of astrocytic inflammation. CK2 enhances NF-κB activity by phosphorylating NF-κB S529 and IκBα S32, promoting pro-inflammatory gene expression. Genetic or chemical CK2 inhibition dampens inflammation, including IL-6 and IL-8 expression in a TNFα acute neuroinflammation mouse model. CK2α2 is upregulated in AD postmortem tissues and patient-derived astrocytes. AD astrocytes exhibit a hyperinflammatory state that can be attenuated by CK2 inhibition. Overexpression of CK2α2 in cortical organoids mimics AD pathology, whereas CK2 inhibition using the potent, selective, and brain-penetrant probe TAL606 rescues inflammatory markers in AD APP/PS1 mice. These findings position CK2 as a central regulator of neuroinflammation and a promising therapeutic target for AD and related disorders.

Indexed as

Alzheimer DiseaseCasein Kinase IINeurodegenerative DiseasesNeurogliaNeuroinflammatory DiseasesAnimalsAstrocytesBrainDisease Models, AnimalFemaleHumansInflammationMaleMiceMice, TransgenicMicrogliaCasein Kinase IINF-kappa B

Identifiers

PMID42014405
PMCPMC13287807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.