ArticleNature communications2026
Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Mechanical, Redox, and Bioelectrical Coupling in Hydrogels for Cutaneous Regeneration: Network Design and Structure-Property Relationships.Gels (Basel, Switzerland) · 2026Review
- Article
- Molecular Design of Underwater Adhesive Copolymers: Synergy Between Long-Chain Alkyl Crystallization-Melting Switching and Carboxyl Group Interfacial Interactions.Materials (Basel, Switzerland) · 2026Article
- Bioadhesive hydrogels as immunomodulatory interfaces for chronic wound healing: from microenvironmental regulation mechanism to engineering strategies.Burns & trauma · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Rapid control of bleeding in complex wounds remains a major clinical challenge. Here, we develop a tissue-adaptive double-network hydrogel that enables instant adhesion to wet tissue and rapid hemostasis. We show that the material can be applied either as an injectable sealant for confined sites or as a conformal patch for large defects. The hydrogel is formed from interpenetrating polymer networks dynamically crosslinked to provide mechanical toughness, rapid self-healing, and shear-thinning injectability. We demonstrate that partial oxidation of catechol groups generates reactive quinone species that form strong bonds with wet tissue without additional activation steps, while incorporated polyphenols accelerate blood clotting. We show that the hydrogel achieves hemostasis within seconds in a mouse liver hemorrhage model and effectively controls bleeding in large-area liver and spleen injuries in rabbits. Finally, we test in a skin incision model to demonstrate that the hydrogel can function as a suture-free adhesive and support healing with minimal scarring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.