ArticleLupus science & medicine2026
Serum lipidomic and metabolomic signatures link epicardial adipose tissue to cardiovascular diseases in SLE: a post-hoc analysis.
Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveCardiovascular diseases are a leading cause of morbidity and mortality in SLE. In this target population, epicardial adipose tissue (EAT) volume is increased, but its determinants and roles are poorly understood. This study aimed to assess the circulating metabolomic and lipidomic signatures associated with EAT in SLE.
methodsA comprehensive analysis of the circulating metabolome and lipidome was conducted in a monocentric and retrospective cohort of patients with SLE followed at the French Referral Center (Pitié-Salpêtrière Hospital) who underwent a cardiac CT scan. Coronary artery calcium (CAC) scores and EAT volumes were collected. An increased indexed EAT (EATi) volume was defined by an EAT volume >68 mL/m
resultsA total of 179 SLE patients were included (mean age, 43±14 years; 100% female). Mean EATi volume was 63±37 mL/m
conclusionsEAT volume is increased and associated with a distinct serum lipidomic and metabolomic signature in SLE.
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