Evidence map›Paper›PMID 42013863›Full record

ArticleImmunity2026

Organ injury in systemic autoimmunity is mediated by stem-like CD8

Jafar Al Souz, Yulong Wei, Can Cui, Rihao Qu, Jin-Young Choi, Fang Wang, Steven J Moioffer, Julia Barrett, Irene Chernova, Manvitha Nadella and 8 more

Abstract read
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. T cells mediate tissue damage in lupus nephritis.Nature reviews. Rheumatology · 2026
    Article
  2. A role for CD8Nature reviews. Immunology · 2026
    Article
  3. CD8Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jafar Al SouzDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Yulong WeiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA.
Can CuiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Rihao QuComputational Biology and Bioinformatics Program, Yale University, New Haven, CT 06520, USA.
Jin-Young ChoiDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT 06520, USA.
Fang WangDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT 06520, USA.
Steven J MoiofferDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Julia BarrettDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Irene ChernovaDepartment of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520, USA.
Manvitha NadellaDepartment of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT 06520, USA.
Emily R SiniscalcoDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Gilbert MoeckelDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.
Nikhil S JoshiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Ping-Min ChenInstitute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Arnon AraziFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030, USA.
Accelerating Medicines Partnership: RA/SLE Network
Ya-Chi HoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA.
Joseph CraftDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Internal Medicine, Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: joseph.craft@yale.edu.

Funding

Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
IMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4M
Yale TMC for Cellular Senescence in Lymphoid OrgansU54AG076043 · NIA · YALE UNIVERSITY · PI FAN, RONG, HALENE, STEPHANIE · 2021 to 2025
$7.0M
Pathogenesis of Lupus NephritisR01AI152443 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft · 2020 to 2026
$3.8M
Using artificial intelligence to bridge human and murine studies of lupus nephritis progressionR01AI180222 · NIAID · UNIVERSITY OF CHICAGO · PI Marcus Ramsay Clark, Joseph Edgar Craft · 2024 to 2026
$2.4M
Follicular Helper T Cell Function in AutoimmunityR01AR074545 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2019 to 2022
$1.3M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
Flow cytometer for high-parameter analysesS10OD026996 · OD · YALE UNIVERSITY · PI HABERMAN, ANN M · 2019 to 2019
$596k
NIAID NIH HHS R01 AI152443NIAID NIH HHS R01 AI180222NIAMS NIH HHS R01 AR074545NIAMS NIH HHS R37 AR040072NIA NIH HHS U54 AG076043NIGMS NIH HHS T32 GM136651NIH HHS S10 OD026996NIH HHS S10 OD030363
6 · The paper itself

Abstract

Although loss of B cell tolerance, autoantibody production, and immune complex deposition are hallmarks of systemic lupus erythematosus (SLE), CD8

Indexed as

AutoimmunityCD8-Positive T-LymphocytesKidneyLupus Erythematosus, SystemicLupus NephritisLymph NodesAnimalsCell DifferentiationFemaleHumansMiceReceptors, Antigen, T-CellReceptors, Antigen, T-CellautoimmunityCD4(+) T cellsCD8(+) T cellscytotoxicitylupus nephritisSLEstem-like T cellsT cell differentiationtissue injury

Identifiers

PMID42013863
PMCPMC13120732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.