Evidence map›Paper›PMID 42013850›Full record

ArticleCell reports. Medicine2026

Distinct signatures in the human gut and oral microbiomes of gastric cancer.

Youwen Qin, Ya-Xuan Zhang, Li-Ping Liu, Yuan-Hong Xie, Xin-Yue Ma, Yu Hao, Li-Cong Zhao, Jiao-Jiao Dong, Ying He, Ke Sun and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Youwen QinShenzhen Hospital, Southern Medical University, Shenzhen, China; BGI Genomics, Shenzhen, China; BGI Genomics, Harbin, China; BGI Research, Shenzhen, China. Electronic address: qinyouwen@genomics.cn.
Ya-Xuan ZhangDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China.
Li-Ping LiuBGI Genomics, Shenzhen, China; BGI Genomics, Harbin, China.
Yuan-Hong XieDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xin-Yue MaDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yu HaoDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li-Cong ZhaoDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jiao-Jiao DongDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Ying HeHarbin Fourth Hospital, Harbin, China.
Ke SunHarbin Sixth Hospital, Harbin, China.
Huanzi ZhongBGI Genomics, Shenzhen, China; BGI Genomics, Harbin, China.
Shida ZhuBGI Genomics, Shenzhen, China; BGI Genomics, Harbin, China.
Ming LiuDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Jing-Yuan FangDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: jingyuanfang@sjtu.edu.cn.
Cheng-Bei ZhouDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: helenairezhou@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiome dysbiosis is increasingly recognized as a hallmark of gastric cancer (GC). Here, we analyzed gut and oral shotgun metagenomic data from 317 individuals across two independent cohorts, with validation in a Harbin cohort. We identify 20 oral-gut shared species enriched in the gut of GC, predominantly lactic acid bacteria (LAB). While most gut microbial markers are abundant in saliva, none are significantly altered in GC. Strain-level analysis of 87 matched saliva-stool metagenomes confirms oral-gut transmission of Streptococcus species. GC-enriched LAB form robust co-abundance networks in oral and gut microbiomes, suggesting synergistic interactions. Functional analysis reveals enriched lactate fermentation pathways in GC stool, aligning with LAB dominance and previous findings on gastric microbiota. Moreover, microbiome-based classifiers achieve high predictive accuracy (area under receiver operating characteristic curve [AUROC] = 0.85 for stool, 0.87 for saliva) for GC diagnosis, highlighting translational potential. Collectively, these findings underscore the critical role of the oral-gut microbiome axis in GC.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaMouthStomach NeoplasmsAgedDysbiosisFecesFemaleHumansMaleMetagenomeMiddle AgedSalivagastric cancerLABlactic acid bacteriamachine learningmicrobiomeoral-gut axisStreptococcus

Identifiers

PMID42013850
PMCPMC13198301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.