ArticleJMIR medical informatics2026
CO
Article in JMIR medical informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fractional carbon dioxide (CO₂) laser resurfacing is widely used for the treatment of scars and photoaging. In recent years, public interest in minimally invasive esthetic procedures has grown, influenced by social media exposure and changing beauty norms. However, data quantifying population-level attention to CO₂ laser treatments in Germany are limited. Objective: This study aimed to assess the long-term trajectory and seasonal patterns of public information-seeking behavior regarding fractional CO₂ laser treatments in Germany from January 2020 to December 2025 using Google Trends data. Methods: Monthly normalized search volume (NSV) for the category "Health" and the term "CO2 laser" was retrieved for the period January 2020 to December 2025. Seasonal-Trend decomposition (STL) using LOESS (locally estimated scatterplot smoothing) was applied to isolate the long-term trend from seasonal fluctuations. The significance of the upward trajectory was assessed using linear regression on the extracted trend component, and seasonal differences were evaluated via the seasonal component amplitude. Results: Public interest in CO₂ lasers increased significantly, with the annual mean NSV rising from 15.0 in 2020 to 68.1 in 2025. Regression analysis of the STL trend component revealed a steady, statistically significant monthly increase (slope=0.87 NSV/month; 95% CI 0.83-0.92; P<.001). Furthermore, a robust seasonal pattern was identified (P<.001), with search interest consistently peaking in winter (January mean SD 13.8) and reaching a nadir during the summer months (August SD=-14.4). Conclusions: Digital information-seeking behavior regarding fractional CO₂ laser treatments in Germany increased by 354% over the past six years, accompanied by consistent, clinically relevant seasonal peaks in winter. These findings reflect broader shifts in esthetic awareness. The identified temporal patterns provide valuable insights for timing educational messaging, managing patient inquiries, and addressing safety considerations in esthetic medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.