Evidence map›Paper›PMID 42013186›Full record

ArticleScience signaling2026

Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca

Khushpreet Kaur, Yael Alippe, Chun Wang, Nicholas P Semenkovich, Mohamed G Hassan, Saumya Bhagat, Kunjan Khanna, Yongjia Li, Nitin Pokhrel, Timothy Peterson and 5 more

Abstract read
In one paragraph

Article in Science signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pyroptotic cell-derived factors promote osteoclast differentiation.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Khushpreet KaurDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8277-6114
Yael AlippeDivision of Rheumatology, Washington University School of Medicine, St. Louis MO 63110, USA.ORCID 0000-0003-2760-7155
Chun WangDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4635-8668
Nicholas P SemenkovichData Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-5266-6734
Mohamed G HassanDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9208-3381
Saumya BhagatDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8979-7455
Kunjan KhannaDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0005-2606-4453
Yongjia LiDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nitin PokhrelDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1538-2019
Timothy PetersonHealthspan Technologies Inc., St. Louis, MO 63110, USA.ORCID 0000-0002-7749-7129
Erica L SchellerDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1551-3816
Deborah J VeisDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-7101-5582
Yousef Abu-AmerDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5890-5086
Roberta FaccioDepartment of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1639-2005
Gabriel MbalavieleDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4660-0952

Funding

DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Skeletal Disorders Training ProgramT32AR060719 · NIAMS · WASHINGTON UNIVERSITY · PI Roberto Civitelli · 2011 to 2026
$4.6M
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitisR01AI161022 · NIAID · WASHINGTON UNIVERSITY · PI CASSAT, JAMES E, MBALAVIELE, GABRIEL · 2021 to 2025
$3.4M
Molecular pathways of calcium pyrophosphate deposition diseaseR01AG077732 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Gabriel Mbalaviele, Ann K Rosenthal · 2022 to 2026
$2.4M
Regulation of Osteoclastogenesis and Inflammatory OsteolysisR01AR082192 · NIAMS · WASHINGTON UNIVERSITY · PI Yousef Abu-Amer · 2023 to 2026
$1.9M
Role of gasdermin D in bone resorptionR01AR076758 · NIAMS · WASHINGTON UNIVERSITY · PI MBALAVIELE, GABRIEL · 2020 to 2024
$1.9M
Novel insulin-sensitizing NASH/diabetes drugs.R42DK121652 · NIDDK · BIOIO, LLC · PI FINCK, BRIAN N, PETERSON, TIMOTHY R · 2019 to 2022
$1.7M
Mechanisms of Physiologic and Pathologic OsteoclastogenesisR01AR072623 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2018 to 2022
$1.7M
Sarm1 and neural regulation of boneR01DK132073 · NIDDK · WASHINGTON UNIVERSITY · PI Erica Lynn Scheller · 2023 to 2026
$1.6M
Cabinet microCT System for Musculoskeletal Specimen ImagingS10OD028573 · OD · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2020 to 2020
$407k
Drug target identification using CRISPRi/a screeningR41GM137625 · NIGMS · BIOIO, LLC · PI GILBERT, LUKE, PETERSON, TIMOTHY R · 2020 to 2020
$224k
NIAID NIH HHS R01 AI161022NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR072623NIAMS NIH HHS R01 AR076758NIAMS NIH HHS R01 AR082192NIAMS NIH HHS T32 AR060719NIA NIH HHS R01 AG077732NIDDK NIH HHS R01 DK132073NIDDK NIH HHS R42 DK121652NIDDK NIH HHS T32 DK007120NIGMS NIH HHS R41 GM137625NIH HHS S10 OD028573
6 · The paper itself

Abstract

Activation of the NLRP3 inflammasome can drive bone resorption by osteoclasts in various inflammatory conditions. Here, we identified Tmem178, a protein that restrains Ca

Indexed as

CalciumInflammasomesMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinOsteoclastsAnimalsBone ResorptionLipopolysaccharidesMacrophagesMiceMice, KnockoutCalciumInflammasomesLipopolysaccharidesMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse

Identifiers

PMID42013186
PMCPMC13685617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.