Evidence map›Paper›PMID 42013009›Full record

ReviewNeuro-degenerative diseases2026

Beyond the Leak: Advanced MRI Assessment of the Blood-Brain Barrier in Neurodegeneration.

Daniele Botta, Caterina Bernetti, Ioana Hutuca, Jose Federico Ojeda Esparza, Lukas Sveikata, Karl Olof Lovblad, Felix T Kurz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-degenerative diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniele BottaDivision of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland, daniele.botta@hug.ch.
Caterina BernettiResearch Unit of Diagnostic Imaging, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Ioana HutucaDivision of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland.
Jose Federico Ojeda EsparzaDivision of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland.
Lukas SveikataDivision of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
Karl Olof LovbladDivision of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland.
Felix T KurzDivision of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Background: The blood-brain barrier (BBB) is a specialized multicellular interface that maintains the central nervous system's tightly regulated microenvironment. BBB disruption is increasingly recognized as a key feature of neurodegeneration, documented across disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and cerebral small vessel disease (cSVD). While the extent to which BBB breakdown is a cause or consequence of neuronal pathology remains unclear, its pronounced presence in disease states suggests a significant contributory role in progression. Summary: This review provides a neuroradiological overview of advanced MRI approaches for assessing BBB integrity in neurodegenerative diseases. The primary quantitative biomarkers discussed are the volume transfer constant (Ktrans) derived from dynamic contrast-enhanced MRI (DCE), reflecting paracellular gadolinium leakage, and the water exchange rate (k

Indexed as

Blood-Brain BarrierMagnetic Resonance ImagingNeurodegenerative DiseasesAnimalsHumansPerfusion Magnetic Resonance ImagingAlzheimer’s diseaseArterial spin labelingBlood-brain barrierCerebral small vessel diseaseDynamic contrast-enhancedMagnetic resonance imaging

Identifiers

PMID42013009
PMCPMC13299135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.